{"id":"W1997488310","doi":"10.1016/s0968-0896(02)00140-2","title":"Design, synthesis, and biological evaluation of a cephalosporin–monohydroguaiaretic acid prodrug activated by a monoclonal antibody–β-lactamase conjugate","year":2002,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Ginger and Zingiberaceae research","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Conjugate; Monoclonal antibody; Chimera (genetics); Cephalosporin; K562 cells; Cancer research; Biochemistry; Antibody; In vitro; Antibiotics; Immunology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002503662,0.0003183423,0.000230282,0.0001928384,0.0001514055,0.0002488984,0.0002675175,0.0003131716,0.0005584576],"category_scores_gemma":[0.0001709569,0.0002026031,0.0002354257,0.0001171761,0.0001885452,0.0001783922,0.0001240812,0.0002969053,0.0002245431],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004281036,"about_ca_system_score_gemma":0.0002639352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006516066,"about_ca_topic_score_gemma":0.0006108964,"domain_scores_codex":[0.9998823,0.00002750245,0.00001192468,0.0000259355,0.00002509932,0.00002719345],"domain_scores_gemma":[0.9999226,0.00001350385,0.0000244393,0.00001101972,0.00001115761,0.00001720558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003215137,0.0001324529,0.0001519201,0.00004051417,0.000009641339,0.0001272755,0.00002522291,0.001140381,0.9931186,0.000213767,0.00004293874,0.004675708],"study_design_scores_gemma":[0.0001112201,0.001554623,0.0004810393,0.000002115888,0.00002082983,0.0001618959,0.000005924803,0.001024942,0.995384,0.00001943496,0.001229952,0.000003985608],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877988,0.001048716,0.009303408,0.00009782793,0.00002889172,0.0002634521,0.0001322095,0.00006083539,0.001265847],"genre_scores_gemma":[0.9939286,0.0004588682,0.004119615,0.00003240799,0.000008003314,0.00005362465,0.0001736738,0.000009594129,0.001215564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006516066,"threshold_uncertainty_score":0.003106177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2043038441443186,"score_gpt":0.431401171151201,"score_spread":0.2270973270068824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}