{"id":"W1997507909","doi":"10.1186/1471-2091-10-23","title":"Monitoring compartment-specific substrate cleavage by cathepsins B, K, L, and S at physiological pH and redox conditions","year":2009,"lang":"en","type":"article","venue":"BMC Biochemistry","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":149,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Jacobs University; National Institutes of Health; Javna Agencija za Raziskovalno Dejavnost RS; Institut \"Jožef Stefan\"","keywords":"Redox; Cleavage (geology); Chemistry; Biochemistry; Substrate (aquarium); Compartment (ship); Substrate specificity; Biophysics; Cathepsin; Enzyme; Biology; Inorganic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003105326,0.000318804,0.0001952295,0.0001852538,0.0001170808,0.000276459,0.0002190077,0.0003122551,0.0008772337],"category_scores_gemma":[0.0003003259,0.00009977425,0.0002120968,0.0002911551,0.0002039428,0.0001962167,0.000160884,0.0003218269,0.0002317067],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002208475,"about_ca_system_score_gemma":0.0002035376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005636347,"about_ca_topic_score_gemma":0.0006203617,"domain_scores_codex":[0.9997826,0.00004471738,0.00001878563,0.00005863187,0.00005529817,0.00003989464],"domain_scores_gemma":[0.9998203,0.00005083646,0.00005424209,0.00001509605,0.00003605852,0.0000234638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001229704,0.00001334607,0.000420051,0.0000528977,0.000007330204,0.00002581807,0.0000230518,0.00004156191,0.998603,0.00001649293,0.00001578923,0.000657547],"study_design_scores_gemma":[0.000008202359,0.0003818011,0.008305088,0.000009352517,0.00002310324,0.0002601798,0.0000548106,0.0008116647,0.9892959,0.00002803173,0.0008144627,0.000007289473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918125,0.002094237,0.004747073,0.00003243192,0.00001520464,0.00003116123,0.0003763867,0.00004103855,0.000850007],"genre_scores_gemma":[0.9879261,0.002013196,0.007691177,0.00004078017,0.00001033788,0.00007471707,0.0007536656,0.00001645571,0.001473516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008772337,"threshold_uncertainty_score":0.002934635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01913555060764317,"score_gpt":0.2535274492971953,"score_spread":0.2343918986895521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}