{"id":"W1997507909","doi":"10.1186/1471-2091-10-23","title":"Monitoring compartment-specific substrate cleavage by cathepsins B, K, L, and S at physiological pH and redox conditions","year":2009,"lang":"en","type":"article","venue":"BMC Biochemistry","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":149,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Jacobs University; National Institutes of Health; Javna Agencija za Raziskovalno Dejavnost RS; Institut \"Jožef Stefan\"","keywords":"Redox; Cleavage (geology); Chemistry; Biochemistry; Substrate (aquarium); Compartment (ship); Substrate specificity; Biophysics; Cathepsin; Enzyme; Biology; Inorganic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005968791,0.0001940983,0.0001458819,0.00001019133,0.0001780884,0.00003564007,0.00009409951,0.000203217,0.00001343703],"category_scores_gemma":[0.00001227571,0.0001856569,0.00004924924,0.00003526573,0.0001271116,0.000005180959,0.00008137518,0.00009590464,0.000005777038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001916899,"about_ca_system_score_gemma":0.00001816748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001612808,"about_ca_topic_score_gemma":4.121282e-7,"domain_scores_codex":[0.9990306,0.00002395231,0.0001589872,0.0004546144,0.0000857112,0.0002460871],"domain_scores_gemma":[0.9994937,0.000006674275,0.0000634357,0.0002577691,0.00002315938,0.0001552518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004538448,0.00007126707,0.0006982906,0.00001424414,0.00001033351,0.000002657565,0.00000835533,3.507978e-7,0.9900868,0.00002472636,0.008909107,0.0001284861],"study_design_scores_gemma":[0.0004808532,0.0001757534,0.003445195,0.00002295348,0.00001090071,0.0000321616,0.00005186425,0.000006051176,0.9931514,0.0001516073,0.002247507,0.0002237882],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934109,0.005637475,0.00006345828,0.00005845549,0.0000525134,0.0001246576,0.00009957187,0.00002653582,0.0005263971],"genre_scores_gemma":[0.9975776,0.0008479163,0.0004221879,0.0000909468,0.0002853343,0.00001706377,0.0002927086,0.00001132774,0.0004549069],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0066616,"threshold_uncertainty_score":0.7570868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01913555060764317,"score_gpt":0.2535274492971953,"score_spread":0.2343918986895521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}