{"id":"W1997528341","doi":"10.1021/bi801538h","title":"Circular Dichroism Spectra and Electrophoretic Mobility Shift Assays Show That Human Replication Protein A Binds and Melts Intramolecular G-Quadruplex Structures<sup>,</sup>","year":2009,"lang":"en","type":"article","venue":"Biochemistry","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"G-quadruplex; Circular dichroism; DNA; Intramolecular force; Electrophoretic mobility shift assay; Binding site; DNA replication; Chemistry; Biophysics; Pyrimidine; Plasma protein binding; Stereochemistry; Crystallography; Biology; Biochemistry; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003138458,0.0006205504,0.0002595269,0.0004560737,0.0002992475,0.0003502285,0.000262519,0.0006663856,0.002858091],"category_scores_gemma":[0.0007449307,0.0003136221,0.0002889624,0.0002919919,0.0004117211,0.0003109225,0.0002066608,0.0007107527,0.001641935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002833126,"about_ca_system_score_gemma":0.0002068999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002798858,"about_ca_topic_score_gemma":0.0003649192,"domain_scores_codex":[0.9994482,0.0001166558,0.00003479583,0.0002214422,0.0001261285,0.00005274095],"domain_scores_gemma":[0.9989347,0.0003775975,0.0003268693,0.00008656987,0.0001606448,0.0001136442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005589389,0.00003248195,0.0006802318,0.00007280495,0.00001195669,0.00004314377,0.00002680959,0.00005275168,0.9946657,0.0001718918,0.00007116395,0.004115143],"study_design_scores_gemma":[0.000006310636,0.0001915052,0.005139225,0.000005673722,0.000009704489,0.0006748902,0.00003109787,0.000688198,0.9907544,0.0001560432,0.002332318,0.00001077878],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9264439,0.005601157,0.05751073,0.0004507778,0.00008950212,0.00009144207,0.0007390904,0.0006348816,0.008438433],"genre_scores_gemma":[0.9440419,0.001591353,0.04810193,0.0002583013,0.00003167552,0.0001075858,0.001297656,0.00007689026,0.00449274],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002858091,"threshold_uncertainty_score":0.0095613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006139739912689728,"score_gpt":0.2298743072904099,"score_spread":0.2237345673777202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}