{"id":"W1997545688","doi":"10.1021/bi027102h","title":"Role of Hydration in the Closed-to-Open Transition Involved in Ca<sup>2+</sup> Binding by Troponin C","year":2003,"lang":"en","type":"article","venue":"Biochemistry","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Glycerol; Troponin C; Urea; Denaturation (fissile materials); Crystallography; Protein subunit; Biophysics; Binding domain; Binding site; Stereochemistry; Biochemistry; Troponin; Nuclear chemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003985793,0.0001030991,0.0002315758,0.00004926736,0.00003473231,0.00001348363,0.00009464103,0.00008858248,0.00001673338],"category_scores_gemma":[0.0001039817,0.00008472021,0.00005519805,0.0002899543,0.00003603317,0.00004060447,0.00001842512,0.0001257758,0.00000462979],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008468569,"about_ca_system_score_gemma":0.00005992862,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001518308,"about_ca_topic_score_gemma":0.00001739841,"domain_scores_codex":[0.9992194,0.00005900509,0.0002263983,0.0001889502,0.0001569938,0.0001492209],"domain_scores_gemma":[0.9996702,0.00003558962,0.00003877149,0.0001926084,0.00002793469,0.0000348667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002158661,0.0002001274,0.003639869,0.00009952082,0.00002582349,0.00001368821,0.007101891,0.00006574267,0.9849401,0.00003353524,0.003164971,0.00049894],"study_design_scores_gemma":[0.001832447,0.00008285607,0.001596624,0.0002048245,0.00004658135,0.00001723744,0.02135593,0.0001825367,0.9724121,0.00005977996,0.002075967,0.0001331002],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929915,0.0007097682,0.00001955215,0.0005780607,0.0000129666,0.0003485573,0.00002582277,0.000006827063,0.005306964],"genre_scores_gemma":[0.9992929,0.00004195939,0.0001101744,0.0002497701,0.00004128518,0.00005983641,0.00008896139,0.000008042364,0.0001071004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01425404,"threshold_uncertainty_score":0.345479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01105267912585972,"score_gpt":0.2532174071416316,"score_spread":0.2421647280157719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}