{"id":"W1997545688","doi":"10.1021/bi027102h","title":"Role of Hydration in the Closed-to-Open Transition Involved in Ca<sup>2+</sup> Binding by Troponin C","year":2003,"lang":"en","type":"article","venue":"Biochemistry","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Glycerol; Troponin C; Urea; Denaturation (fissile materials); Crystallography; Protein subunit; Biophysics; Binding domain; Binding site; Stereochemistry; Biochemistry; Troponin; Nuclear chemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000184454,0.0002413902,0.0002112076,0.00007596595,0.0002873049,0.0003685796,0.000316691,0.0003629266,0.0008570432],"category_scores_gemma":[0.0004010553,0.0001626928,0.0001338981,0.00004957837,0.0007775701,0.0006265837,0.0003861033,0.0003648541,0.0001722503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003019393,"about_ca_system_score_gemma":0.0002078098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006858975,"about_ca_topic_score_gemma":0.0004913674,"domain_scores_codex":[0.9999132,0.00001670503,0.000005395862,0.00002162505,0.00001753723,0.00002560667],"domain_scores_gemma":[0.9997979,0.00006212978,0.00005395057,0.000009997896,0.00001896037,0.00005702633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005132817,0.00007374548,0.003160491,0.00007894896,0.0000150309,0.0002873076,0.0001979839,0.0003085785,0.9915727,0.0005781002,0.00007141498,0.003142427],"study_design_scores_gemma":[0.00009418969,0.0005931743,0.04992611,0.00004177912,0.00003763506,0.0007258151,0.000371613,0.01501815,0.9303272,0.00134292,0.001471302,0.0000501814],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977425,0.0004428314,0.001158023,0.00006568206,0.000009971901,0.00001199586,0.00002670921,0.00002989373,0.0005123294],"genre_scores_gemma":[0.9993787,0.00008771538,0.0003569132,0.00001377776,0.000002389824,0.000004237722,0.00002079719,0.000007570814,0.0001280054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008570432,"threshold_uncertainty_score":0.002867162,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01105267912585972,"score_gpt":0.2532174071416316,"score_spread":0.2421647280157719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}