{"id":"W1997591291","doi":"10.1007/s00213-008-1196-6","title":"Mice with reduced NMDA receptor glycine affinity model some of the negative and cognitive symptoms of schizophrenia","year":2008,"lang":"en","type":"article","venue":"Psychopharmacology","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":142,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"F. Hoffmann-La Roche","keywords":"NMDA receptor; Clozapine; Schizophrenia (object-oriented programming); Psychology; Novelty; Glycine; Endophenotype; Neuroscience; Atypical antipsychotic; Cognitive flexibility; Psychosis; Cognition; Antipsychotic; Pharmacology; Chemistry; Receptor; Biochemistry; Psychiatry; Biology; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007063073,0.0001575906,0.0002508979,0.00003511447,0.00007126146,0.000001405038,0.0001599945,0.0001193607,0.00002278123],"category_scores_gemma":[0.00003971343,0.0001098703,0.00006278905,0.0001115754,0.0005712993,0.000006269816,0.00008949784,0.00013085,0.000001242276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000384751,"about_ca_system_score_gemma":0.0001125636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001537425,"about_ca_topic_score_gemma":0.000005161804,"domain_scores_codex":[0.9991428,0.00008919519,0.0002111447,0.0002819828,0.00009416507,0.0001807711],"domain_scores_gemma":[0.9993702,0.00003237496,0.000209075,0.0001619869,0.0001583898,0.00006803515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002782359,0.0001257347,0.0005908262,0.00001855261,0.0001900935,4.640383e-7,0.0002452267,0.00007000822,0.9940039,0.00008467004,0.0009678366,0.0009203267],"study_design_scores_gemma":[0.005348913,0.000477649,0.007272838,0.00001893943,0.0001030346,0.00001949377,0.00006730935,0.0001121404,0.9860247,0.00007454948,0.0003297118,0.0001506827],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976357,0.0010754,0.0001262774,0.0001394931,0.000232692,0.0002897304,0.00008470704,0.000005361963,0.0004106688],"genre_scores_gemma":[0.9974688,0.0007488551,0.0008127073,0.0004106137,0.0001529162,0.00002885432,0.00001264163,0.00001811134,0.0003465522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007979164,"threshold_uncertainty_score":0.4480383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01003970121985376,"score_gpt":0.2588078703118594,"score_spread":0.2487681690920057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}