{"id":"W1997599409","doi":"10.1016/j.expneurol.2011.01.014","title":"Folate deficiency increases mtDNA and D-1 mtDNA deletion in aged brain of mice lacking uracil-DNA glycosylase","year":2011,"lang":"en","type":"article","venue":"Experimental Neurology","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"Brock University","funders":"Center for Stroke Research Berlin; Volkswagen Foundation; Eli Lilly and Company","keywords":"Mitochondrial DNA; Uracil-DNA glycosylase; Uracil; DNA glycosylase; DNA; Genetics; Biology; Mitochondrion; Molecular biology; DNA repair; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002177982,0.0008466993,0.000617876,0.001430057,0.0003425437,0.0004792429,0.0005777997,0.0008825576,0.003017322],"category_scores_gemma":[0.0002752888,0.0007601815,0.0004615012,0.0004066448,0.0008518152,0.0006592159,0.0003583043,0.001474297,0.0005278921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005496172,"about_ca_system_score_gemma":0.0004535425,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003024651,"about_ca_topic_score_gemma":0.004244305,"domain_scores_codex":[0.999729,0.0000267094,0.00003710599,0.00007418075,0.00005111401,0.00008195984],"domain_scores_gemma":[0.9993383,0.00007203978,0.0002643934,0.00004847567,0.00005420984,0.000222612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001007492,0.00006547939,0.0004066844,0.00003980641,0.00002743016,0.000197988,0.00004280113,0.00004246339,0.9974501,0.0001078919,0.00005219477,0.0005597385],"study_design_scores_gemma":[0.0001077416,0.0007363955,0.02035849,0.0000231545,0.0001714697,0.001338528,0.0002272941,0.0006734995,0.9745772,0.0002497105,0.001515404,0.00002104208],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996365,0.001329682,0.0008234549,0.0001610073,0.0000376219,0.000009833382,0.0007206507,0.00008389376,0.0004688675],"genre_scores_gemma":[0.9895518,0.001508518,0.00132376,0.0001101737,0.00002856679,0.00004437035,0.0008372677,0.0001034574,0.006492155],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003024651,"threshold_uncertainty_score":0.01009399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01248308307246278,"score_gpt":0.2402000278766019,"score_spread":0.2277169448041391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}