{"id":"W1997632499","doi":"10.1074/jbc.m113.476424","title":"The Fer Tyrosine Kinase Is Important for Platelet-derived Growth Factor-BB-induced Signal Transducer and Activator of Transcription 3 (STAT3) Protein Phosphorylation, Colony Formation in Soft Agar, and Tumor Growth in Vivo","year":2013,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Queen's University; Cancerfonden; Ludwig Institute for Cancer Research; Cancer Research Institute","keywords":"Platelet-derived growth factor receptor; Autophosphorylation; STAT protein; STAT3; Tyrosine phosphorylation; Cell biology; Biology; Platelet-derived growth factor; Tyrosine kinase; Growth factor; Kinase; Phosphorylation; Cancer research; Molecular biology; Signal transduction; Chemistry; Biochemistry; Protein kinase A; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001231801,0.0004617654,0.000180814,0.0001868043,0.0002609815,0.0002587381,0.0001236916,0.0002777416,0.001691618],"category_scores_gemma":[0.0001115251,0.0001257845,0.0003208401,0.0001259939,0.000207643,0.0001898656,0.0001696379,0.0004254656,0.0009043618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004211387,"about_ca_system_score_gemma":0.0002061666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000478855,"about_ca_topic_score_gemma":0.0005335878,"domain_scores_codex":[0.9998678,0.00001470416,0.00001022915,0.0000276413,0.00003994311,0.00003962592],"domain_scores_gemma":[0.9999046,0.00001020882,0.00004113191,0.000006558268,0.00001143399,0.0000260587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001183128,0.00001023711,0.0001676855,0.00003396772,0.000003389467,0.00007417217,0.000006095428,0.00004184158,0.9980539,0.0001149463,0.00006297954,0.001312586],"study_design_scores_gemma":[0.00002964047,0.0001868293,0.01395999,0.00001528668,0.00003647321,0.001472346,0.00003103508,0.0009697991,0.9725338,0.0001389811,0.01061577,0.00001000111],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9743356,0.009955784,0.009633533,0.0003851976,0.0001135022,0.00005255849,0.001211959,0.0002254049,0.00408651],"genre_scores_gemma":[0.9911808,0.002220957,0.001958405,0.00006450559,0.00002020833,0.0000219383,0.001282732,0.00002187613,0.003228597],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001691618,"threshold_uncertainty_score":0.005658984,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0242870897437253,"score_gpt":0.2489674280631393,"score_spread":0.224680338319414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}