{"id":"W1997648709","doi":"10.1016/j.chom.2007.02.002","title":"Type III Secretion Effectors of the IpaH Family Are E3 Ubiquitin Ligases","year":2007,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":313,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"","keywords":"Effector; Ubiquitin ligase; Biology; Ubiquitin; Secretion; Cell biology; Shigella flexneri; Type three secretion system; Ubiquitin-Protein Ligases; Proteasome; Shigella; Microbiology; Genetics; Escherichia coli; Biochemistry; Gene; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001841398,0.0006002208,0.0004417866,0.0002570015,0.000298171,0.0007887576,0.0001629131,0.00026006,0.001596122],"category_scores_gemma":[0.0002703157,0.0001289842,0.0003569834,0.0002929628,0.0002101618,0.0004002702,0.0004070489,0.0004527578,0.001468722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003924054,"about_ca_system_score_gemma":0.0001578073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001461517,"about_ca_topic_score_gemma":0.0001451653,"domain_scores_codex":[0.9998485,0.00001994719,0.00001067571,0.00002690303,0.00005375767,0.00004018664],"domain_scores_gemma":[0.9998721,0.00001541752,0.00003511729,0.0000162612,0.00003281934,0.00002831819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006910605,0.00005085242,0.005666339,0.0001272649,0.00002834845,0.0007289787,0.00003210732,0.0002661967,0.9666767,0.001469603,0.001257112,0.02300533],"study_design_scores_gemma":[0.00003614959,0.0002596781,0.0311096,0.00001553198,0.00004869068,0.00495316,0.00009206084,0.002982331,0.9287143,0.0008693403,0.03089735,0.00002171848],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9482238,0.01002149,0.02857773,0.0005174738,0.0002143664,0.00007404568,0.001957278,0.001081697,0.009332166],"genre_scores_gemma":[0.9731407,0.003366142,0.009991442,0.0002332124,0.0000932786,0.00003747214,0.002683814,0.00006927476,0.01038471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001596122,"threshold_uncertainty_score":0.005339563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008529428897621316,"score_gpt":0.2255015433925442,"score_spread":0.2169721144949228,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}