{"id":"W1997682097","doi":"10.1021/bi802243j","title":"Conformational Stability and Membrane Interaction of the Full-Length Ectodomain of HIV-1 gp41: Implication for Mode of Action","year":2009,"lang":"en","type":"article","venue":"Biochemistry","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Ectodomain; Gp41; Membrane; Chemistry; Biophysics; Circular dichroism; Coiled coil; Lipid bilayer fusion; Vesicle; Lipid bilayer; Crystallography; Biochemistry; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000128368,0.000210247,0.0001174081,0.0001174987,0.0001338271,0.0002780156,0.0001411597,0.0002648361,0.0003250836],"category_scores_gemma":[0.0002053514,0.0000792288,0.0001055575,0.00009085991,0.0002194977,0.000263166,0.0001543825,0.0002459532,0.0001149557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001850011,"about_ca_system_score_gemma":0.00008330675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002290118,"about_ca_topic_score_gemma":0.000144721,"domain_scores_codex":[0.999913,0.00001668761,0.000005819396,0.00001924911,0.00003265804,0.00001254556],"domain_scores_gemma":[0.9999217,0.00002220657,0.00002216905,0.00000802136,0.00001433839,0.00001156349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002744751,0.000006142723,0.0003463718,0.000007281861,0.000001930671,0.00001820195,0.00000957334,0.00002673881,0.9990504,0.00002812723,0.000004046068,0.0004736872],"study_design_scores_gemma":[0.000006303151,0.0001633267,0.01876055,0.000002940247,0.000007621316,0.0005682452,0.00004853127,0.001312241,0.9786606,0.00009118413,0.000371726,0.000006724294],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998719,0.0005376763,0.0005164615,0.00003421454,0.000001802346,0.000002887414,0.00003548102,0.000005268103,0.0001473027],"genre_scores_gemma":[0.9991473,0.0002387849,0.0003594003,0.0000140909,0.000002427134,0.000004608155,0.00005688432,0.000002209699,0.0001743935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003250836,"threshold_uncertainty_score":0.001342237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01806218450652159,"score_gpt":0.2973015435066192,"score_spread":0.2792393590000976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}