{"id":"W1997682097","doi":"10.1021/bi802243j","title":"Conformational Stability and Membrane Interaction of the Full-Length Ectodomain of HIV-1 gp41: Implication for Mode of Action","year":2009,"lang":"en","type":"article","venue":"Biochemistry","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Ectodomain; Gp41; Membrane; Chemistry; Biophysics; Circular dichroism; Coiled coil; Lipid bilayer fusion; Vesicle; Lipid bilayer; Crystallography; Biochemistry; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000779398,0.00004514435,0.00009075819,0.0000132634,0.00003088594,0.000001172497,0.00005091745,0.00007074238,0.00004548937],"category_scores_gemma":[0.00006149703,0.00003285125,0.00004301856,0.00002986319,0.00009267812,0.00003269358,0.0000116319,0.00004682953,0.000001318811],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002627935,"about_ca_system_score_gemma":0.00004531752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001317116,"about_ca_topic_score_gemma":0.000001852642,"domain_scores_codex":[0.9996493,0.00002065215,0.0001675892,0.00007299066,0.00002510128,0.00006431526],"domain_scores_gemma":[0.9995667,0.00007097716,0.0001342171,0.0001336402,0.00008669067,0.000007792581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003606513,0.0001138672,0.0003474793,0.00009834263,0.00003830825,6.563432e-9,0.00008438565,0.00000211263,0.9964196,0.00009281246,0.0001448962,0.002297534],"study_design_scores_gemma":[0.0006545985,0.00009182021,0.005122974,0.00001482109,0.00001379621,0.000006218272,0.0001591533,0.00003374247,0.9936686,0.00008768635,0.0001228177,0.00002376318],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987057,0.0001008892,0.0001821163,0.0001774193,0.00002101291,0.0001708112,0.0003686001,0.000003636487,0.0002698085],"genre_scores_gemma":[0.9995382,0.00002040351,0.00007084854,0.000002713923,0.000005222821,0.00001066875,0.0002960256,0.000001313865,0.00005460095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004775494,"threshold_uncertainty_score":0.1339635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01806218450652159,"score_gpt":0.2973015435066192,"score_spread":0.2792393590000976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}