{"id":"W1997685083","doi":"10.1016/j.aquatox.2013.03.013","title":"Effects of TDCPP or TPP on gene transcriptions and hormones of HPG axis, and their consequences on reproduction in adult zebrafish (Danio rerio)","year":2013,"lang":"en","type":"article","venue":"Aquatic Toxicology","topic":"Toxic Organic Pollutants Impact","field":"Environmental Science","cited_by":296,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"National Research Foundation of Korea","keywords":"Internal medicine; Downregulation and upregulation; Endocrinology; Biology; Zebrafish; Danio; Hypothalamic–pituitary–gonadal axis; Steroidogenic acute regulatory protein; Estrogen receptor; Vitellogenin; Cholesterol side-chain cleavage enzyme; Hormone; Luteinizing hormone; Andrology; Cytochrome P450; Gene expression; Gene; Metabolism; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000220437,0.0001495857,0.0003037287,0.00008209899,0.00004437186,0.000007908276,0.0001107056,0.0001135053,0.0003334626],"category_scores_gemma":[0.000632147,0.0001065641,0.00002265016,0.0002035869,0.0006659887,0.0001401535,0.00003268655,0.0001118993,0.00002918283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006818071,"about_ca_system_score_gemma":0.00002293864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006342664,"about_ca_topic_score_gemma":0.0009356365,"domain_scores_codex":[0.9987959,0.0001852212,0.0003196196,0.0003548641,0.0001214988,0.0002228914],"domain_scores_gemma":[0.9991345,0.0003960324,0.000144446,0.0002471205,0.000002662697,0.00007517185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008315122,0.0001899782,0.001338519,0.00001928967,0.00001542721,0.000004126824,0.001502699,0.000009308364,0.9560542,0.00007720356,0.00008432259,0.04062182],"study_design_scores_gemma":[0.000849482,0.00208061,0.4307536,0.000047027,0.00001734876,0.00005395789,0.0003461665,0.000237997,0.5635563,0.001900151,0.00002720812,0.0001301315],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972072,0.0001141218,0.00003522357,0.001682954,0.0001168939,0.0005708407,0.00001359923,0.00001559183,0.000243599],"genre_scores_gemma":[0.9990637,0.0002082638,0.0003158492,0.0002682453,0.00001576943,0.00002361014,4.451145e-7,0.0000113424,0.00009271647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4294151,"threshold_uncertainty_score":0.4345558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01014987409010683,"score_gpt":0.2209794432544603,"score_spread":0.2108295691643535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}