{"id":"W1997697682","doi":"10.1136/jmg.2006.044974","title":"A large germline deletion in the Chek2 kinase gene is associated with an increased risk of prostate cancer","year":2006,"lang":"en","type":"article","venue":"Journal of Medical Genetics","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"Coalition for Research in Women's Health","funders":"","keywords":"Germline; CHEK2; Prostate cancer; Checkpoint Kinase 2; Genetics; Gene; Biology; Cancer research; Germline mutation; Oncology; Medicine; Cancer; Kinase; Bioinformatics; Mutation; Protein kinase A; Protein-Serine-Threonine Kinases","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002829765,0.0003880678,0.0003130519,0.0007212761,0.0002739517,0.0003072799,0.0002609053,0.0003071182,0.002522845],"category_scores_gemma":[0.001435448,0.0002398995,0.0002506031,0.0006740973,0.0003601862,0.0001302963,0.0003516088,0.0003567002,0.0002105469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001285871,"about_ca_system_score_gemma":0.0002207614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001806653,"about_ca_topic_score_gemma":0.00140208,"domain_scores_codex":[0.9997615,0.0000444781,0.000022983,0.00008546691,0.0000508715,0.00003466635],"domain_scores_gemma":[0.9990933,0.0001722438,0.0004989971,0.0000637889,0.00005849072,0.0001131976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004480308,0.00002919903,0.9880524,0.00003814315,0.0002231797,0.0006821332,0.00005414441,0.00009491952,0.007298897,0.0000369787,0.0001253705,0.002916584],"study_design_scores_gemma":[0.00002426169,0.0001206093,0.9941881,0.00001210886,0.0001346923,0.004272067,0.00004843349,0.0001659991,0.0007425923,0.00005271323,0.00023419,0.000004193998],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991875,0.0003326479,0.000160468,0.00002528911,0.000004150637,0.000003797132,0.00009595885,0.000009220429,0.0001809345],"genre_scores_gemma":[0.9994894,0.0001677841,0.000125583,0.00001242009,0.000008523519,0.000002626762,0.0001015914,0.000002712526,0.00008926861],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002522845,"threshold_uncertainty_score":0.008439779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006398297333374893,"score_gpt":0.2659734250527319,"score_spread":0.259575127719357,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}