{"id":"W1997710934","doi":"10.1515/bc.2008.118","title":"Substrate specificity determination of mouse implantation serine proteinase and human kallikrein-related peptidase 6 by phage display","year":2008,"lang":"en","type":"article","venue":"Biological Chemistry","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital; University of Calgary","funders":"","keywords":"Biopanning; Kallikrein; Trypsin; Serine; Biochemistry; Phage display; Serine protease; Peptide library; Enzyme; Chymotrypsin; Chemistry; Molecular biology; Proteases; Tryptophan; Peptide; Proteinase 3; Protease; Biology; Amino acid; Peptide sequence; Gene; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008975669,0.0001661957,0.0002639179,0.00001700947,0.00010632,0.000007201909,0.00005401178,0.0001956535,0.0002287663],"category_scores_gemma":[0.00005211825,0.0001300848,0.00006700495,0.00008577354,0.0002222871,0.00005679561,0.00002521013,0.0001191317,0.000004023682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002714391,"about_ca_system_score_gemma":0.00001902996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004250327,"about_ca_topic_score_gemma":0.000001677165,"domain_scores_codex":[0.99905,0.00002061338,0.0003490705,0.0002814945,0.0001264571,0.0001723682],"domain_scores_gemma":[0.9994606,0.00003883251,0.0001640243,0.000143927,0.00006610936,0.000126555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001394304,0.0001893785,0.0569357,0.0001101698,0.0000123615,0.00005144016,0.00005651956,3.456462e-7,0.9419581,0.0000346685,0.00006541008,0.0004464981],"study_design_scores_gemma":[0.001134629,0.0002075781,0.1789806,0.00003664095,0.00002099605,0.0001877667,0.00003010142,0.00008243048,0.8190049,0.00005518017,0.0001151721,0.0001439666],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986345,0.0002827628,0.00004552868,0.00004319759,0.0000110653,0.0002509591,0.0000647674,0.00006726645,0.0005999339],"genre_scores_gemma":[0.9970304,0.0001149755,0.0001746731,0.00002029243,0.00005567212,0.0000154617,0.0007523921,0.00001015141,0.001825952],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1229532,"threshold_uncertainty_score":0.5304703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02484655444834223,"score_gpt":0.2611111880728771,"score_spread":0.2362646336245349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}