{"id":"W1997718533","doi":"10.1074/jbc.m109.061622","title":"GREBP, a cGMP-response Element-binding Protein Repressing the Transcription of Natriuretic Peptide Receptor 1 (NPR1/GCA)","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Nuclear Receptors and Signaling","field":"Neuroscience","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Biology; NPR1; Chromatin immunoprecipitation; Molecular biology; Luciferase; NPR2; Atrial natriuretic peptide; Transcription (linguistics); SOX4; Gene expression; Promoter; Gene; Natriuretic peptide; Biochemistry; Transfection; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001287497,0.0001457527,0.0002623821,0.00003417324,0.0001627856,0.00005900105,0.0004691468,0.0001866157,0.001087501],"category_scores_gemma":[0.002389511,0.0000833515,0.0002434539,0.0001737355,0.0002831923,0.0001026599,0.00004947994,0.0008864464,0.000006859906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003326915,"about_ca_system_score_gemma":0.00005616533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001156712,"about_ca_topic_score_gemma":8.644754e-8,"domain_scores_codex":[0.9983624,0.0002241358,0.0006045122,0.0002196429,0.0003484555,0.0002408287],"domain_scores_gemma":[0.9986414,0.0003387498,0.0006341304,0.000187401,0.00009143733,0.000106842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007119476,0.00007666749,0.0002022781,0.00002209615,0.00000684393,0.000009730741,0.000101165,0.000004038775,0.9977508,0.00004040575,0.00008887403,0.000985104],"study_design_scores_gemma":[0.0003734626,0.0001749683,0.00008457006,0.0001003853,0.00001174379,0.0001358959,0.0001770427,0.00003929669,0.994512,0.0001812516,0.004104359,0.0001050355],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998556,0.00004600402,0.00007758281,0.0005709461,0.000206292,0.0001204807,0.000008010786,0.00001600898,0.0003986371],"genre_scores_gemma":[0.9986679,0.00002414771,0.0006897617,0.0000522868,0.0002412006,0.000002848644,6.538673e-7,0.00001175059,0.0003094587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004015484,"threshold_uncertainty_score":0.9998257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03493998894192433,"score_gpt":0.267446999671388,"score_spread":0.2325070107294637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}