{"id":"W1997724371","doi":"10.2174/1567269054087640","title":"Nucleic Acid-Based Gene-Silencing Molecules as Potential Antiviral Therapeutics","year":2005,"lang":"en","type":"article","venue":"Drug Design Reviews - Online","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"","keywords":"Ribozyme; Small interfering RNA; Gene silencing; Deoxyribozyme; RNA; Nucleic acid; Biology; RNA interference; Trans-acting siRNA; Sense (electronics); RNA silencing; Aptamer; Ligase ribozyme; Computational biology; Gene; DNA; Chemistry; Molecular biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003081359,0.0008121317,0.0006106613,0.0006086873,0.0001904522,0.0006859425,0.0005537447,0.00116635,0.04099837],"category_scores_gemma":[0.000248962,0.0002448012,0.0004480018,0.0005065823,0.000338296,0.0009669851,0.000724623,0.001559726,0.007062705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005300114,"about_ca_system_score_gemma":0.0002352417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001964511,"about_ca_topic_score_gemma":0.0004836385,"domain_scores_codex":[0.9998485,0.000034718,0.000008630215,0.00002985102,0.00004959984,0.00002870747],"domain_scores_gemma":[0.9999282,0.00001546591,0.00002049332,0.000006165852,0.00001377997,0.00001577413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0004554111,0.0003168418,0.0004321273,0.01208565,0.0002603916,0.001095032,0.0001189965,0.009054465,0.4850754,0.07905181,0.1130577,0.2989962],"study_design_scores_gemma":[0.0001590245,0.001015438,0.001028157,0.0004883927,0.0001302269,0.000586358,0.00006135548,0.005903547,0.2220353,0.01542764,0.7530577,0.0001068981],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.07718781,0.6168212,0.07504767,0.01351464,0.01428734,0.0009680771,0.006320921,0.00243366,0.1934186],"genre_scores_gemma":[0.5491526,0.3384086,0.02717047,0.005674968,0.003507489,0.0008989701,0.003330734,0.0002293735,0.07162687],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.04099837,"threshold_uncertainty_score":0.1371532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02944425828062414,"score_gpt":0.2923848892882288,"score_spread":0.2629406310076046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}