{"id":"W1997733493","doi":"10.1074/jbc.m706067200","title":"Characterization of Some Molecular Mechanisms Governing Autoactivation of the Catalytic Domain of the Anaplastic Lymphoma Kinase","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Università degli Studi di Perugia; Associazione Italiana per la Ricerca sul Cancro; Università degli Studi di Padova; National Cancer Institute; Fondazione Cariplo; European Commission","keywords":"Autophosphorylation; Anaplastic lymphoma kinase; Anaplastic large-cell lymphoma; Tyrosine kinase; Protein kinase domain; Receptor tyrosine kinase; Chemistry; Cyclin-dependent kinase 9; Biology; Kinase; Molecular biology; Cancer research; Mitogen-activated protein kinase kinase; Cell biology; Mutant; Biochemistry; Signal transduction; Protein kinase A; Lymphoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001559706,0.0002486603,0.0001244161,0.0001559669,0.00009966908,0.0001981311,0.000257605,0.000232879,0.0004513569],"category_scores_gemma":[0.0001718227,0.0001114564,0.0002368004,0.00007512832,0.0001786799,0.0002053135,0.00009508802,0.0003685991,0.0001843035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002369922,"about_ca_system_score_gemma":0.000139913,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004559648,"about_ca_topic_score_gemma":0.0002881108,"domain_scores_codex":[0.9999158,0.00001758578,0.000007756543,0.00001515399,0.00002084678,0.00002281402],"domain_scores_gemma":[0.9998823,0.00004720375,0.00002715203,0.00001597096,0.00001122897,0.00001613634],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003679074,0.0000199416,0.0002996386,0.00001229645,0.000003219243,0.00005800296,0.000005828262,0.0001600632,0.9986999,0.0001501308,0.000004213614,0.0005499694],"study_design_scores_gemma":[0.00001701799,0.0001176732,0.006729297,0.000003685575,0.00001436492,0.000691994,0.00001986586,0.004592515,0.9867482,0.0001338187,0.0009265389,0.000004985261],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962187,0.0009562248,0.00220659,0.00002542952,0.000004583422,0.0000133495,0.00006721525,0.00001026121,0.0004976331],"genre_scores_gemma":[0.9979635,0.0004472843,0.001055156,0.00001827193,0.000004504335,0.00001580891,0.0002127756,0.000004728252,0.0002778706],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004559648,"threshold_uncertainty_score":0.001719475,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01049586949022987,"score_gpt":0.2275029266669796,"score_spread":0.2170070571767497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}