{"id":"W1997739855","doi":"10.1021/bi035189g","title":"Detailed Dissection of a New Mechanism for Glycoside Cleavage:  α-1,4-Glucan Lyase","year":2003,"lang":"en","type":"article","venue":"Biochemistry","topic":"Enzyme Production and Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Chemistry; Glycosidic bond; Stereochemistry; Kinetic isotope effect; Bond cleavage; Leaving group; Hemiacetal; Oxocarbenium; Deuterium; Enzyme; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008201301,0.0001179233,0.0001008846,0.00001782198,0.00004714913,0.00001098608,0.00007673658,0.0001499879,0.00003524009],"category_scores_gemma":[0.0002571052,0.0001255082,0.00008614685,0.00006892021,0.00002379043,0.000003285503,0.00001540667,0.00003969214,0.000002145743],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001346356,"about_ca_system_score_gemma":0.0001116202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002629598,"about_ca_topic_score_gemma":0.000005098056,"domain_scores_codex":[0.9993015,0.00001522649,0.0001860201,0.0002853919,0.0000730596,0.0001387988],"domain_scores_gemma":[0.9994304,0.000003815403,0.0001120654,0.0002676912,0.0001038737,0.00008220497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008239203,0.0000469761,0.0003041749,0.00005401812,0.00002253723,2.051811e-7,0.00001303481,0.000001338247,0.9957561,0.0005346937,0.002852409,0.0003320666],"study_design_scores_gemma":[0.00056488,0.00008774405,0.0001281642,0.000009688195,0.00002094599,0.0000182898,0.00006857384,0.000009264541,0.9921736,0.0003042379,0.006476367,0.0001382175],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830993,0.0001316093,0.0155439,0.0001137098,0.0002178334,0.0001698557,0.00002107628,0.00001784994,0.0006848706],"genre_scores_gemma":[0.9923784,0.00004365795,0.002101529,0.0001018656,0.0002795313,0.00002649641,0.0002482653,0.00002117524,0.004799065],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01344237,"threshold_uncertainty_score":0.5118077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0100790163875012,"score_gpt":0.2442882558158812,"score_spread":0.23420923942838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}