{"id":"W1997751445","doi":"10.1371/journal.ppat.0030024","title":"Essential Gene Identification and Drug Target Prioritization in Aspergillus fumigatus","year":2007,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":242,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Genome Canada","keywords":"Aspergillus fumigatus; Biology; Candida albicans; Aspergillosis; Gene; Antifungal drug; Microbiology; Mutant; Fungal protein; Computational biology; Immunology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004900057,0.0001024609,0.0001863243,0.000110744,0.00006309752,0.00001665471,0.00003743529,0.00008049123,0.000049411],"category_scores_gemma":[0.0002098298,0.0001000343,0.00004057229,0.0002257144,0.00006398751,0.00009020596,0.00002105273,0.0001230027,0.00002338425],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007786806,"about_ca_system_score_gemma":0.00005003993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001650395,"about_ca_topic_score_gemma":0.0001398237,"domain_scores_codex":[0.9988517,0.00003354771,0.0003246639,0.0003054294,0.0002523975,0.0002323076],"domain_scores_gemma":[0.9994543,0.00004026988,0.00006047691,0.0002246954,0.0001101357,0.0001101669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000111029,0.0001587635,0.3667547,0.0000724971,0.00001065512,0.00007631788,0.0003910345,0.00000127102,0.6311558,0.0001317573,0.00003888252,0.001097329],"study_design_scores_gemma":[0.0005277523,0.00002740083,0.8265203,0.00004290866,0.00004171441,0.000008734034,0.0002464417,0.0002829364,0.1719046,0.0001825808,0.0001147808,0.00009988707],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956417,0.0006159332,0.002484512,0.0001709624,0.00009348637,0.0003343039,0.00001893557,0.00004256083,0.0005975907],"genre_scores_gemma":[0.9975009,0.0001832485,0.001408287,0.00008152607,0.0001482793,0.000005536018,0.0000982049,0.00001557694,0.0005584231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4597656,"threshold_uncertainty_score":0.4079281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01041617865989165,"score_gpt":0.2593257671296465,"score_spread":0.2489095884697549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}