{"id":"W1997759747","doi":"10.1002/(sici)1097-0290(20000520)68:4<381::aid-bit3>3.0.co;2-d","title":"Enhanced growth of sf-9 cells to a maximum density of 5.2 × 107 cells per mL and production of β-galactosidase at high cell density by fed batch culture","year":2000,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute; National Research Council Canada","funders":"","keywords":"Bioreactor; Fed-batch culture; Nutrient; Cell culture; Biomass (ecology); Cell growth; Biology; Food science; Capacitance; Productivity; Chromatography; Chemistry; Fermentation; Animal science; Biochemistry; Botany; Agronomy; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007099772,0.001052826,0.00132878,0.0004041404,0.0002034217,0.0006777612,0.0007210156,0.0006544692,0.001074203],"category_scores_gemma":[0.0003484775,0.0002784071,0.0006422226,0.0006096704,0.0002536582,0.0003695232,0.0004202722,0.001358347,0.001250897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006128658,"about_ca_system_score_gemma":0.0002764358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001291357,"about_ca_topic_score_gemma":0.00183927,"domain_scores_codex":[0.9995928,0.00007047387,0.00005198505,0.00008241092,0.0001607318,0.00004156793],"domain_scores_gemma":[0.9997857,0.00006219328,0.00003211815,0.00003454863,0.00005284934,0.00003264336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002890696,0.00002825649,0.00004885539,0.00003909181,0.00000466415,0.00002245986,0.000008691481,0.00004493517,0.9988167,0.00003250631,0.00004918614,0.0008757472],"study_design_scores_gemma":[0.00002428247,0.0002622817,0.001511098,0.00001137158,0.00003026501,0.0002152737,0.00001010631,0.002311542,0.9927153,0.00004374343,0.002856045,0.000008704776],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.883794,0.00403628,0.09722669,0.0004890737,0.0003398305,0.000657493,0.005527532,0.001163711,0.006765321],"genre_scores_gemma":[0.7699198,0.003500184,0.2041439,0.0002492903,0.00008574579,0.0004718061,0.01069133,0.0002608022,0.01067731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00132878,"threshold_uncertainty_score":0.004446685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002398664565500341,"score_gpt":0.1794276743032282,"score_spread":0.1770290097377279,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}