{"id":"W1997762052","doi":"10.1371/journal.pone.0061557","title":"Proprotein Convertase 1/3 (PC1/3) in the Rat Alveolar Macrophage Cell Line NR8383: Localization, Trafficking and Effects on Cytokine Secretion","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Centre National de la Recherche Scientifique; Fonds Québécois de la Recherche sur la Nature et les Technologies; Ministère du Développement Économique, de l’Innovation et de l’Exportation","keywords":"Cell biology; Innate immune system; Secretion; Rab; Biology; Lysosome; Alveolar macrophage; Macrophage; Small hairpin RNA; Receptor; Toll-like receptor; Regulator; Cell culture; Gene knockdown; Immune system; Immunology; GTPase; Endocrinology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001955028,0.0003723009,0.0003582656,0.0002363113,0.0002613246,0.0002936577,0.0002572204,0.0003911704,0.0009786433],"category_scores_gemma":[0.0001147628,0.0001533801,0.0004081151,0.0003803598,0.0002470867,0.0002112763,0.0002135603,0.0008803667,0.001082171],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003562968,"about_ca_system_score_gemma":0.0003253511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001847352,"about_ca_topic_score_gemma":0.002059174,"domain_scores_codex":[0.9996092,0.00004642407,0.00005929455,0.00007025727,0.0001306823,0.00008414469],"domain_scores_gemma":[0.99981,0.00002725584,0.0000505973,0.0000454301,0.00003067936,0.00003606273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000886437,0.00003923822,0.0001090176,0.00002250019,0.000001884643,0.00007939138,0.00001586077,0.00003070189,0.9990729,0.00003572442,0.00002639625,0.0004777382],"study_design_scores_gemma":[0.00001965553,0.0003759288,0.005199163,0.000005301052,0.00001477439,0.0004296175,0.00004733137,0.0004738366,0.9919802,0.00002841268,0.001419517,0.00000626184],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938886,0.001420554,0.001804316,0.0001543822,0.00003143145,0.00003862026,0.001398752,0.0001013841,0.001161982],"genre_scores_gemma":[0.9865103,0.001449272,0.004514299,0.0001004047,0.00001183979,0.0001350453,0.002408916,0.0000437889,0.004826102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001847352,"threshold_uncertainty_score":0.003673136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008976549475414996,"score_gpt":0.1843008274945569,"score_spread":0.1753242780191419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}