{"id":"W1997763925","doi":"10.3109/15368370903206606","title":"Electrostatic Contributions to Colchicine Binding within Tubulin Isotypes","year":2009,"lang":"en","type":"article","venue":"Electromagnetic Biology and Medicine","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Allard Foundation; Alberta Cancer Foundation","keywords":"Tubulin; Colchicine; Microtubule; Biology; Binding site; Plasma protein binding; Cell biology; Protein subunit; Biophysics; Chemistry; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002835403,0.0002055521,0.0002861087,0.0001101172,0.0001529755,0.000006889976,0.0001279898,0.0002039028,0.00004090909],"category_scores_gemma":[0.0003229138,0.0001655307,0.00003168242,0.0001950683,0.000156762,0.000002316357,0.00003015702,0.0001822723,0.00001232676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001807691,"about_ca_system_score_gemma":0.0000750313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002076666,"about_ca_topic_score_gemma":0.00006297462,"domain_scores_codex":[0.9987336,0.00008033875,0.000281637,0.000402889,0.00005772781,0.000443823],"domain_scores_gemma":[0.9994017,0.00002964735,0.00006805333,0.0002212807,0.00009455114,0.0001848007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001506176,0.00003750387,0.0003022876,0.000004926113,0.00002958694,0.000002569929,0.00007472043,0.000001246637,0.9872569,0.005576247,0.004156042,0.002407328],"study_design_scores_gemma":[0.006180585,0.05900504,0.01382026,0.0001472432,0.0003158596,0.0005869096,0.0001776193,0.0002038448,0.8355212,0.01123438,0.07176901,0.001038085],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818491,0.004241845,0.002836325,0.009631225,0.0001370043,0.0003757654,0.00002363171,0.00002797748,0.0008771559],"genre_scores_gemma":[0.9908177,0.0009080376,0.0008916962,0.005457121,0.0003832014,0.00001958785,0.0003104123,0.00001216762,0.001200024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1517358,"threshold_uncertainty_score":0.6750147,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004100060979062119,"score_gpt":0.27851913768357,"score_spread":0.2744190767045079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}