{"id":"W1997763925","doi":"10.3109/15368370903206606","title":"Electrostatic Contributions to Colchicine Binding within Tubulin Isotypes","year":2009,"lang":"en","type":"article","venue":"Electromagnetic Biology and Medicine","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Allard Foundation; Alberta Cancer Foundation","keywords":"Tubulin; Colchicine; Microtubule; Biology; Binding site; Plasma protein binding; Cell biology; Protein subunit; Biophysics; Chemistry; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001804873,0.0004421034,0.0003236246,0.0003493703,0.0006468561,0.0004933263,0.0004164605,0.0003217373,0.004094594],"category_scores_gemma":[0.0007208978,0.0002308674,0.0002019389,0.0003051973,0.0004466124,0.0002830367,0.0003317673,0.0003229848,0.0003298438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008813932,"about_ca_system_score_gemma":0.0004982442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004354556,"about_ca_topic_score_gemma":0.004956144,"domain_scores_codex":[0.9998224,0.00002722625,0.000006512966,0.00002590167,0.00005621185,0.00006162529],"domain_scores_gemma":[0.999715,0.0001374179,0.0000464377,0.00001108833,0.00004329741,0.00004675677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001456631,0.0002202883,0.01002147,0.0006160951,0.0001731758,0.002985739,0.0003605818,0.1642805,0.7710513,0.02847629,0.00102643,0.01933154],"study_design_scores_gemma":[0.0002290906,0.0006477836,0.02023167,0.00004997934,0.0003628737,0.001364331,0.0004533252,0.5031748,0.4595449,0.008823212,0.004980285,0.0001376877],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9726284,0.001129282,0.01148681,0.0002060333,0.00007477639,0.00003108351,0.00008805268,0.00009413704,0.01426139],"genre_scores_gemma":[0.9974664,0.0004493355,0.0006813803,0.00003882517,0.000009503046,0.00001157345,0.00005448188,0.00002367347,0.001264752],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004354556,"threshold_uncertainty_score":0.0136978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004100060979062119,"score_gpt":0.27851913768357,"score_spread":0.2744190767045079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}