{"id":"W1997809789","doi":"10.1074/jbc.m506407200","title":"Binding Site Characterization and Resistance to a Class of Non-nucleoside Inhibitors of the Hepatitis C Virus NS5B Polymerase","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Hepatitis C virus research","field":"Medicine","cited_by":122,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"Boehringer Ingelheim","keywords":"NS5B; Replicon; RNA polymerase; Polymerase; Allosteric regulation; Biology; RNA-dependent RNA polymerase; Binding site; RNA; Carboxamide; Biochemistry; Benzimidazole; Hepatitis C virus; Chemistry; Molecular biology; Enzyme; Virology; Virus; Gene; Hepacivirus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001462385,0.0002332179,0.0002470017,0.0002569391,0.0001129638,0.0001441052,0.0001862837,0.0003128517,0.0008372926],"category_scores_gemma":[0.0004103563,0.00009562605,0.0002010356,0.0001982063,0.000110277,0.0001052059,0.00008345934,0.0002593778,0.0002789441],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001317782,"about_ca_system_score_gemma":0.00009995786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001104494,"about_ca_topic_score_gemma":0.00105487,"domain_scores_codex":[0.9998091,0.00002981036,0.00002075743,0.00003444246,0.00008175617,0.00002417314],"domain_scores_gemma":[0.9998423,0.00003880791,0.00004174956,0.00002108477,0.00003254927,0.00002349259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007645039,0.00004298698,0.0006855531,0.00001079691,0.000005134572,0.00002246491,0.000007665272,0.0001369885,0.9969339,0.00001734393,0.00002114807,0.002039629],"study_design_scores_gemma":[0.00001709166,0.0007431551,0.01206717,0.000002781911,0.00002474605,0.0006016464,0.00001511479,0.001872086,0.9835687,0.0000157147,0.001064165,0.00000756652],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965546,0.0006885288,0.001545795,0.00002949405,0.000006624775,0.00003614237,0.0004331214,0.00003002232,0.0006755985],"genre_scores_gemma":[0.9946052,0.0003521846,0.002851995,0.00003522489,0.000004812869,0.000020756,0.001381985,0.00001491547,0.0007328528],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001104494,"threshold_uncertainty_score":0.002801061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01877040167387236,"score_gpt":0.2842056413607598,"score_spread":0.2654352396868875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}