{"id":"W1997811592","doi":"10.1016/s0165-6147(00)01575-3","title":"Pharmacological chaperones: a new twist on receptor folding","year":2000,"lang":"en","type":"review","venue":"Trends in Pharmacological Sciences","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":240,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôpital du Sacré-Cœur de Montréal; Université de Montréal","funders":"","keywords":"Co-chaperone; Protein folding; Mutant; Chemical chaperone; Chaperone (clinical); Folding (DSP implementation); Receptor; Cell biology; Mutation; Function (biology); Biology; Computational biology; Intracellular; Chemistry; Biochemistry; Hsp90; Gene; Medicine; Heat shock protein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003769867,0.0006228328,0.001000157,0.0002813321,0.0002047526,0.00006779764,0.001077934,0.0004759586,0.006683652],"category_scores_gemma":[0.00007207477,0.0003978542,0.0005589682,0.0009000311,0.0005494778,0.00000933455,0.0002383842,0.0004731824,0.0001689802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007604295,"about_ca_system_score_gemma":0.0002520433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001372564,"about_ca_topic_score_gemma":0.000004295491,"domain_scores_codex":[0.9964054,0.0003772365,0.0006404545,0.001355116,0.0004069061,0.000814846],"domain_scores_gemma":[0.9989662,0.0001349424,0.000224023,0.0001927533,0.00001319918,0.0004688868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008562994,0.000353005,0.00001752364,0.0001139318,0.00006384235,0.00005377219,0.00000716266,0.00005673353,0.0002725106,0.00007180971,0.02552765,0.9733765],"study_design_scores_gemma":[0.0006948225,0.0007866758,0.00001046475,0.0004809874,0.0002693194,0.00001658772,0.000007538189,0.00002241742,0.000245775,0.000039508,0.9968579,0.0005679692],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003019046,0.9755545,0.000002664947,0.0001429238,0.0005890648,0.000380815,0.00007795555,0.00004953653,0.02018354],"genre_scores_gemma":[0.002943506,0.9929373,0.0002064881,0.0005573999,0.0008443065,0.0001878599,0.0001593102,0.00002407054,0.002139739],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9728085,"threshold_uncertainty_score":0.9998474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1083736226348819,"score_gpt":0.4306641820649342,"score_spread":0.3222905594300522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}