{"id":"W1997873681","doi":"10.1016/j.bbrc.2010.10.020","title":"ERK phosphorylation and tumor necrosis factor-alpha production by monocytes are persistent in response to immobilized IgG","year":2010,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; Sunnybrook Health Science Centre; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Internalization; Phosphorylation; Immune system; Tumor necrosis factor alpha; Receptor; MAPK/ERK pathway; Cell biology; Cytokine; Chemistry; Immunoglobulin G; Secretion; Biology; Molecular biology; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00042039,0.000624057,0.000541874,0.0003374897,0.0003203878,0.0007520402,0.0003662357,0.000522545,0.003218855],"category_scores_gemma":[0.0005260384,0.0003991322,0.0006679431,0.0004039235,0.0004204792,0.0003150086,0.000332441,0.001211651,0.000935359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005022656,"about_ca_system_score_gemma":0.0004328161,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001782167,"about_ca_topic_score_gemma":0.002518913,"domain_scores_codex":[0.9992433,0.00009813234,0.0000636162,0.00007415165,0.0001297992,0.0003910617],"domain_scores_gemma":[0.9996575,0.000104578,0.00004192696,0.00006357336,0.00005446863,0.0000778871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002955699,0.0001292126,0.000481178,0.00006349121,0.00001447535,0.0001105741,0.00003988809,0.00004060021,0.9949042,0.00005809724,0.00009893556,0.001103714],"study_design_scores_gemma":[0.0002110788,0.0007424564,0.02754859,0.00001857452,0.00005879133,0.0002259562,0.00009834275,0.0008508547,0.9690974,0.00008869356,0.001044572,0.00001459358],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948534,0.0014548,0.001261893,0.000196442,0.0001113506,0.00003895998,0.0004913223,0.00004676758,0.001545074],"genre_scores_gemma":[0.9926797,0.0006985962,0.001136919,0.0001315768,0.0001019775,0.0000848938,0.001401341,0.00001431837,0.003750677],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003218855,"threshold_uncertainty_score":0.01076818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06360910398383174,"score_gpt":0.3809397288424736,"score_spread":0.3173306248586419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}