{"id":"W1997886998","doi":"10.1016/j.chom.2014.01.010","title":"Caspase-1 Cleavage of the TLR Adaptor TRIF Inhibits Autophagy and β-Interferon Production during Pseudomonas aeruginosa Infection","year":2014,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"Biotechnology and Biological Sciences Research Council","keywords":"TRIF; Autophagy; Biology; Pseudomonas aeruginosa; Signal transducing adaptor protein; Cleavage (geology); Microbiology; Interferon; Inflammasome; Cell biology; Apoptosis; Immunology; Signal transduction; Immune system; Innate immune system; Biochemistry; Inflammation; Toll-like receptor; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003912292,0.0003345576,0.0004691124,0.0002382319,0.0002385924,0.0004239363,0.0002577571,0.0005057703,0.00184813],"category_scores_gemma":[0.0003929356,0.0002239698,0.0003868509,0.0001625421,0.0003434634,0.0004538606,0.0002477423,0.00109502,0.0005949405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004355791,"about_ca_system_score_gemma":0.0003879023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003209487,"about_ca_topic_score_gemma":0.0005317096,"domain_scores_codex":[0.9995995,0.00008374177,0.00004955351,0.0000391876,0.00007115393,0.0001568829],"domain_scores_gemma":[0.9998077,0.0000425466,0.00004695657,0.00002882731,0.00002161507,0.00005247149],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002986965,0.0001884919,0.0002315911,0.00008174851,0.00001343255,0.0001023543,0.00003094449,0.0001542667,0.9942237,0.0001629639,0.0001759498,0.001647669],"study_design_scores_gemma":[0.0002252671,0.001017284,0.006808413,0.00001685523,0.00002708788,0.0004652945,0.00009046697,0.001796514,0.9884498,0.0001546964,0.0009350241,0.00001325767],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996137,0.001198576,0.0009579192,0.0001865026,0.00006526255,0.00002975979,0.0002568376,0.00004652584,0.001121585],"genre_scores_gemma":[0.9977371,0.0003382996,0.0005186012,0.00006436358,0.00001732156,0.00003443473,0.0003066439,0.000007836777,0.0009754607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00184813,"threshold_uncertainty_score":0.006182611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002605816547413635,"score_gpt":0.1754661839983915,"score_spread":0.1728603674509779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}