{"id":"W1997887534","doi":"10.1016/j.bpj.2009.12.804","title":"The Perturbation of the Open-Closed Transition of Troponin C by the Mutation L48Q Leads to an Enhanced Troponin I Affinity","year":2010,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Troponin C; Troponin complex; Actin; Troponin; Chemistry; Biophysics; Troponin I; Heteronuclear single quantum coherence spectroscopy; Tropomyosin; Stereochemistry; Mutant; Biochemistry; Crystallography; Nuclear magnetic resonance spectroscopy; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000281855,0.000500317,0.0005265458,0.000260341,0.0004224249,0.0003083448,0.0005668041,0.001256166,0.003860519],"category_scores_gemma":[0.0009681955,0.0002716312,0.0005103988,0.0001258098,0.00080268,0.0003675148,0.0005067158,0.001266032,0.001086638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002360525,"about_ca_system_score_gemma":0.0001919495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006916889,"about_ca_topic_score_gemma":0.0003717503,"domain_scores_codex":[0.9996616,0.00007095018,0.00003375085,0.00007214684,0.00009051157,0.00007108414],"domain_scores_gemma":[0.999447,0.0002060331,0.0001091366,0.00006423626,0.00004740664,0.000126113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001451458,0.00003072812,0.0002145458,0.00001331211,0.00000564931,0.0003123469,0.00003033261,0.00005176799,0.9985256,0.00009039044,0.00003697219,0.0005433949],"study_design_scores_gemma":[0.0001344724,0.0005346084,0.009752681,0.00001047166,0.00002824273,0.003077257,0.00005278917,0.001451327,0.9833514,0.0003675582,0.001207788,0.00003141547],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963567,0.0002458982,0.002072676,0.0001819228,0.0000643571,0.00001899566,0.0001414947,0.00007788531,0.0008399779],"genre_scores_gemma":[0.9986042,0.0000657428,0.0005881964,0.00007702409,0.00001590145,0.00001538162,0.0001072777,0.00003917704,0.0004869674],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003860519,"threshold_uncertainty_score":0.01291478,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01230942104987953,"score_gpt":0.2852101245695496,"score_spread":0.2729007035196701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}