{"id":"W1997907161","doi":"10.1124/jpet.103.053389","title":"Inhibition of Canine (NCX1.1) and Drosophila (CALX1.1) Na+-Ca2+ Exchangers by 7-Chloro-3,5-dihydro-5-phenyl-1 H-4,1-benzothiazepine-2-one (CGP-37157)","year":2003,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Boniface Hospital","funders":"","keywords":"Sodium-calcium exchanger; Chemistry; Potency; Stereochemistry; Biophysics; Sodium; Ion exchange; Pharmacology; Biochemistry; In vitro; Ion; Biology; Intracellular","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002094795,0.0002911421,0.0003076516,0.0001602375,0.0001578392,0.0002759345,0.0004159545,0.0003212169,0.001696242],"category_scores_gemma":[0.0001829656,0.0001634069,0.0002801087,0.0001291925,0.0003532224,0.000217538,0.0002106592,0.0006773123,0.0004523622],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000506544,"about_ca_system_score_gemma":0.0004059788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001132384,"about_ca_topic_score_gemma":0.00231269,"domain_scores_codex":[0.9998378,0.00001708623,0.00001694159,0.00002610855,0.00004231141,0.00005978313],"domain_scores_gemma":[0.9998945,0.00002766087,0.00002234688,0.00001317747,0.000008172125,0.0000340825],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004121939,0.00006110564,0.0001319897,0.00005217389,0.000008174908,0.00006460736,0.00002265353,0.0000899502,0.9969104,0.0004018951,0.0001654571,0.001679358],"study_design_scores_gemma":[0.0001908102,0.0006216534,0.003567784,0.000008782792,0.0000217682,0.0002362987,0.00003513254,0.00133873,0.9908888,0.00008910631,0.002994294,0.000006952215],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939929,0.001649637,0.001046312,0.0002639679,0.00006622303,0.00003440097,0.0003136948,0.0001062608,0.002526512],"genre_scores_gemma":[0.9915934,0.001732194,0.001310942,0.0001091116,0.00002663358,0.00007631051,0.0007924946,0.0000308794,0.004328183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001696242,"threshold_uncertainty_score":0.005674422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02035372039823616,"score_gpt":0.2943127834923035,"score_spread":0.2739590630940674,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}