{"id":"W1997911959","doi":"10.1016/j.ab.2005.02.007","title":"A fluorogenic substrate for the continuous assaying of aryl sulfatases","year":2005,"lang":"en","type":"article","venue":"Analytical Biochemistry","topic":"Chemical Reaction Mechanisms","field":"Chemistry","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"","keywords":"Substrate (aquarium); Chemistry; Coumarin; Aryl; Fluorescence; Stereochemistry; Chromatography; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001797802,0.0002006499,0.0002791487,0.00001507444,0.0000778407,0.00003167136,0.0003733897,0.0002106753,0.001131025],"category_scores_gemma":[0.000725725,0.0001558599,0.0004014761,0.0001275524,0.0001703196,0.0000454593,0.00006679264,0.0002378359,0.00002578833],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007992656,"about_ca_system_score_gemma":0.00007736414,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001036959,"about_ca_topic_score_gemma":0.000001854231,"domain_scores_codex":[0.9985916,0.00000235367,0.0004331504,0.0003460899,0.000276515,0.0003502692],"domain_scores_gemma":[0.9982278,0.0008079718,0.0001540931,0.0005269567,0.0001320311,0.0001511426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006739757,0.0001111264,0.0001190326,0.0001082372,0.0001587629,0.000002143307,0.000008085131,0.00001249248,0.9942341,0.0004391633,0.001781661,0.002957759],"study_design_scores_gemma":[0.000495262,0.000009462851,0.000007373736,0.00003421052,0.0002131308,0.00001966421,0.0001500607,0.003855241,0.9898062,0.0002299332,0.005001722,0.0001777252],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992762,0.000846352,0.001265582,0.001014578,0.00003398968,0.000102882,0.0002419012,0.00009441013,0.00363825],"genre_scores_gemma":[0.9973297,0.00003567506,0.0005362107,0.0001247865,0.0003372183,0.00003250444,0.0001083011,0.00002449141,0.001471085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004567672,"threshold_uncertainty_score":0.9997821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01827873382833141,"score_gpt":0.2705256926790464,"score_spread":0.252246958850715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}