{"id":"W1997927100","doi":"10.1002/art.20496","title":"Release of hyaluronan and hyaladherins (aggrecan G1 domain and link proteins) from articular cartilage exposed to ADAMTS‐4 (aggrecanase 1) or ADAMTS‐5 (aggrecanase 2)","year":2004,"lang":"en","type":"article","venue":"Arthritis & Rheumatism","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Aggrecanase; Aggrecan; ADAMTS; Cartilage; Chemistry; Glycosaminoglycan; Ex vivo; Cell biology; Proteoglycan; Molecular biology; Biochemistry; Extracellular matrix; Biology; In vitro; Pathology; Osteoarthritis; Medicine; Articular cartilage; Matrix metalloproteinase; Anatomy; Metalloproteinase; Thrombospondin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003089649,0.0006311861,0.001142299,0.0002915105,0.0002583028,0.00009381461,0.0001628352,0.0002691268,0.0003726238],"category_scores_gemma":[0.0002688647,0.0005834169,0.000165312,0.0004014194,0.0002989199,0.0003309524,0.0001808039,0.0003040374,0.00006513488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001523614,"about_ca_system_score_gemma":0.0003969457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00289759,"about_ca_topic_score_gemma":0.009844813,"domain_scores_codex":[0.9964139,0.0001388539,0.0009775638,0.0009766798,0.0006890174,0.0008039299],"domain_scores_gemma":[0.9973422,0.0001194415,0.0003088659,0.0008306611,0.0001592325,0.001239637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00138368,0.0005778089,0.001873641,0.0001672643,0.000168721,0.00307215,0.00516321,0.00001239747,0.1695844,0.001569343,0.0002109233,0.8162165],"study_design_scores_gemma":[0.09026139,0.04288918,0.01791021,0.02862023,0.0007783304,0.00296898,0.004891515,0.0001205465,0.7844112,0.01238851,0.01151192,0.003247962],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9801537,0.01417945,0.0003502147,0.001730404,0.0002305124,0.002549182,0.0003799117,0.0001751393,0.0002514624],"genre_scores_gemma":[0.9722033,0.003098382,0.02312577,0.0005714038,0.0001180573,0.0003276858,0.0001601728,0.0001219054,0.0002733637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8129685,"threshold_uncertainty_score":0.9996617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01111932623427024,"score_gpt":0.2237215990960613,"score_spread":0.2126022728617911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}