{"id":"W1997927100","doi":"10.1002/art.20496","title":"Release of hyaluronan and hyaladherins (aggrecan G1 domain and link proteins) from articular cartilage exposed to ADAMTS‐4 (aggrecanase 1) or ADAMTS‐5 (aggrecanase 2)","year":2004,"lang":"en","type":"article","venue":"Arthritis & Rheumatism","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Aggrecanase; Aggrecan; ADAMTS; Cartilage; Chemistry; Glycosaminoglycan; Ex vivo; Cell biology; Proteoglycan; Molecular biology; Biochemistry; Extracellular matrix; Biology; In vitro; Pathology; Osteoarthritis; Medicine; Articular cartilage; Matrix metalloproteinase; Anatomy; Metalloproteinase; Thrombospondin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000214813,0.0005569678,0.0003394403,0.0001831677,0.0001527695,0.000346843,0.0002010582,0.0003713382,0.001367088],"category_scores_gemma":[0.0001808627,0.0001988755,0.0004447654,0.0001356498,0.0002929846,0.000268512,0.000182428,0.0003965665,0.0004588455],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003269478,"about_ca_system_score_gemma":0.0002691795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005740044,"about_ca_topic_score_gemma":0.0006049722,"domain_scores_codex":[0.9997864,0.00002168541,0.00002228936,0.00004388309,0.00007324127,0.00005242661],"domain_scores_gemma":[0.9998077,0.00002973459,0.00005455573,0.00003238522,0.00002936937,0.00004634927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008800974,0.00001041936,0.000131373,0.00002513663,0.000005579931,0.00004594772,0.00001087812,0.000009753303,0.9993654,0.000006647726,0.000006853915,0.0002938847],"study_design_scores_gemma":[0.00002127102,0.0003985631,0.008070137,0.000008084372,0.00002098129,0.0002191032,0.00003200738,0.0002481441,0.9904166,0.00001307805,0.0005476721,0.000004315985],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945202,0.002933543,0.001580502,0.00005053588,0.00003489729,0.00003338056,0.0002804837,0.0000323285,0.0005342677],"genre_scores_gemma":[0.9931697,0.001088264,0.001520401,0.00005416779,0.0000262529,0.0000499944,0.0008216689,0.00001248704,0.003256999],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001367088,"threshold_uncertainty_score":0.004573405,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01111932623427024,"score_gpt":0.2237215990960613,"score_spread":0.2126022728617911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}