{"id":"W1997958675","doi":"10.1371/journal.pone.0040448","title":"Structural Interaction and Functional Regulation of Polycystin-2 by Filamin","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Medical Research Council; Canadian Institutes of Health Research; National Institute of Diabetes and Digestive and Kidney Diseases; Consejo Nacional de Investigaciones Científicas y Técnicas; Fondation pour la Recherche Médicale; National Natural Science Foundation of China; Kidney Foundation of Canada; Rutgers Cancer Institute of New Jersey; University of Alberta; National Institutes of Health; National Science Foundation","keywords":"Filamin; Cell biology; FLNA; Ankyrin; Actin cytoskeleton; Signal transduction; Scaffold protein; Actin; Ion channel; Cytoskeleton; Biology; G protein-coupled receptor; Immunoprecipitation; TRPC1; Chemistry; Receptor; Biochemistry; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001175088,0.000218483,0.0001340855,0.0001101534,0.0001999176,0.0003510416,0.0002720522,0.0003139685,0.0004340626],"category_scores_gemma":[0.0001870929,0.0001324255,0.0002463207,0.000102125,0.0002890547,0.0002437564,0.0002311339,0.0004162367,0.0002078637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004525196,"about_ca_system_score_gemma":0.0001138203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006588704,"about_ca_topic_score_gemma":0.0005977836,"domain_scores_codex":[0.9998358,0.00003727984,0.00001791836,0.00003394167,0.00004163875,0.00003342747],"domain_scores_gemma":[0.9998646,0.0000265018,0.00004230157,0.00001735133,0.0000203615,0.00002884246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004930582,0.000007289969,0.0001289746,0.000009116226,0.000002367359,0.0000531115,0.000006085104,0.00002807698,0.9994792,0.00004668035,0.000006790185,0.0001829587],"study_design_scores_gemma":[0.000009682329,0.00005519106,0.01095109,0.000003285546,0.00001125804,0.0004909139,0.00004228801,0.001200064,0.986503,0.00005454162,0.0006735746,0.000005177237],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980018,0.0005902245,0.0009404358,0.00006171715,0.00001006988,0.000004056696,0.00006051615,0.00001127399,0.0003199241],"genre_scores_gemma":[0.998642,0.0002616064,0.0005884066,0.0000248984,0.000003077867,0.000006306923,0.0001084917,0.000007162591,0.000357935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006588704,"threshold_uncertainty_score":0.003283262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02154402533853357,"score_gpt":0.2156079569146805,"score_spread":0.194063931576147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}