{"id":"W1997970555","doi":"10.1111/dom.12357","title":"The interleukin‐1 receptor antagonist anakinra improves first‐phase insulin secretion and insulinogenic index in subjects with impaired glucose tolerance","year":2014,"lang":"en","type":"letter","venue":"Diabetes Obesity and Metabolism","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Radboud Universiteit; Novo Nordisk Fonden; European Foundation for the Study of Diabetes","keywords":"Anakinra; Medicine; Internal medicine; Interleukin 1 receptor antagonist; Endocrinology; Placebo; Insulin; Receptor antagonist; Type 2 diabetes; Antagonist; Diabetes mellitus; Impaired glucose tolerance; Interleukin; Insulin resistance; Receptor; Cytokine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005361187,0.0005033608,0.000799965,0.0001944767,0.0002829557,0.0003040466,0.0003312597,0.001282627,0.001089896],"category_scores_gemma":[0.001441703,0.0001528457,0.0002703719,0.0001667534,0.0002773283,0.0002924164,0.00007315599,0.000932285,0.0004494397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000292,"about_ca_system_score_gemma":0.000210618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005093036,"about_ca_topic_score_gemma":0.000757442,"domain_scores_codex":[0.999744,0.0001376474,0.00002515009,0.0000275273,0.00004128528,0.00002446489],"domain_scores_gemma":[0.9995141,0.0002955554,0.00004413561,0.00002735423,0.00006233604,0.00005657749],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1371697,0.01074933,0.1573998,0.001593462,0.0008396821,0.05180901,0.000654258,0.0007742441,0.120002,0.0009132234,0.06081574,0.4572796],"study_design_scores_gemma":[0.03313651,0.09395584,0.6780241,0.0004062716,0.00113343,0.07511499,0.0005793988,0.005699052,0.04047051,0.00270243,0.06862205,0.000155405],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9558652,0.01008419,0.0009357879,0.02489662,0.002182826,0.0001756513,0.0001779365,0.0001661525,0.005515707],"genre_scores_gemma":[0.966381,0.00463595,0.00118226,0.01917559,0.003146041,0.000108651,0.000137204,0.00002197587,0.005211432],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001282627,"threshold_uncertainty_score":0.003646076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004010870474421166,"score_gpt":0.1989291215263735,"score_spread":0.1949182510519523,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}