{"id":"W1997970555","doi":"10.1111/dom.12357","title":"The interleukin‐1 receptor antagonist anakinra improves first‐phase insulin secretion and insulinogenic index in subjects with impaired glucose tolerance","year":2014,"lang":"en","type":"letter","venue":"Diabetes Obesity and Metabolism","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Radboud Universiteit; Novo Nordisk Fonden; European Foundation for the Study of Diabetes","keywords":"Anakinra; Medicine; Internal medicine; Interleukin 1 receptor antagonist; Endocrinology; Placebo; Insulin; Receptor antagonist; Type 2 diabetes; Antagonist; Diabetes mellitus; Impaired glucose tolerance; Interleukin; Insulin resistance; Receptor; Cytokine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004434775,0.0005560413,0.0006482707,0.0001175923,0.0003554134,0.0002555278,0.0003319253,0.0008650862,0.000003828288],"category_scores_gemma":[0.0001290578,0.0004219254,0.0001320717,0.0002092689,0.0003990388,0.00002180823,0.0001909575,0.0008067172,0.000003073319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002372439,"about_ca_system_score_gemma":0.00009423769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001243596,"about_ca_topic_score_gemma":0.0003809173,"domain_scores_codex":[0.9975586,0.000231167,0.0004126212,0.0008123547,0.0002326302,0.0007526519],"domain_scores_gemma":[0.9988684,0.00008567039,0.0003417678,0.0004749339,0.0001045843,0.0001246265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002777213,0.002323432,0.2985397,0.003452206,0.003906505,0.0001237946,0.002345914,0.00006196058,0.2654766,0.0002017681,0.2533773,0.1674136],"study_design_scores_gemma":[0.005117781,0.0005651778,0.05222655,0.0002349685,0.0001877581,0.000003829069,0.00008633253,0.0003963251,0.01723285,0.0001638029,0.9227232,0.001061389],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9630598,0.02295131,0.000009571251,0.012967,0.0002839005,0.0005250346,0.0001379084,0.00002511381,0.00004040261],"genre_scores_gemma":[0.9443892,0.01026768,0.00004883948,0.04286458,0.0009563427,0.0001144222,0.001129265,0.00007562914,0.0001540017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6693459,"threshold_uncertainty_score":0.9998233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004010870474421166,"score_gpt":0.1989291215263735,"score_spread":0.1949182510519523,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}