{"id":"W1997971768","doi":"10.2147/ijn.s39048","title":"Characterization of cellular uptake and toxicity of aminosilane-coated iron oxide nanoparticles with different charges in central nervous system-relevant cell culture models","year":2013,"lang":"en","type":"article","venue":"International Journal of Nanomedicine","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Manitoba Health Research Council","keywords":"Viability assay; Iron oxide nanoparticles; Chemistry; Cytotoxicity; Biophysics; Biocompatibility; MTT assay; Toxicity; Pharmacology; Biochemistry; Cell; Iron oxide; In vitro; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002443309,0.0003242308,0.0002437071,0.0002879658,0.0001424609,0.0001549343,0.0001912727,0.0003053792,0.0004161415],"category_scores_gemma":[0.0001568181,0.00009263589,0.0002745617,0.0001738771,0.0001773495,0.0001329668,0.000104489,0.0002517526,0.0001315169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003135465,"about_ca_system_score_gemma":0.000200161,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001536186,"about_ca_topic_score_gemma":0.001677679,"domain_scores_codex":[0.9998751,0.00001424211,0.00001275957,0.00002816143,0.00004976776,0.00001992902],"domain_scores_gemma":[0.9998497,0.0000378066,0.0000314457,0.0000101336,0.00005662024,0.00001431344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000440432,0.00002072412,0.0001745777,0.0000301726,0.00000443364,0.00004294227,0.00002098295,0.00009253654,0.9989541,0.00001694532,0.00001182534,0.0005866373],"study_design_scores_gemma":[0.000007142679,0.0003843041,0.003257417,0.00000490184,0.00001976463,0.0001212433,0.0000249704,0.001302788,0.9944819,0.00001335179,0.0003784456,0.000003697098],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927717,0.001067656,0.004851506,0.00003343392,0.00001888755,0.00005565174,0.0001667624,0.00003553541,0.000998807],"genre_scores_gemma":[0.9889084,0.001112185,0.007491239,0.00005231795,0.0000135062,0.0001755122,0.000475139,0.00002268953,0.001749058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001536186,"threshold_uncertainty_score":0.0030545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007679725826914559,"score_gpt":0.1971189147229882,"score_spread":0.1894391888960736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}