{"id":"W1997996171","doi":"10.1042/bj20060015","title":"Conformational and functional characterization of trapped complexes of the P-glycoprotein multidrug transporter","year":2006,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"Transporter; P-glycoprotein; Chemistry; Multiple drug resistance; Characterization (materials science); Glycoprotein; Biochemistry; Stereochemistry; Computational biology; Biology; Gene; Nanotechnology; Materials science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008906083,0.00007037011,0.0001594585,0.0000382513,0.00004380459,0.000004352259,0.00003744378,0.00005771758,0.0001213202],"category_scores_gemma":[0.000003542579,0.00004329416,0.0001010234,0.00006770365,0.0001296285,0.00004805985,0.000003382686,0.0001188741,3.628171e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009516109,"about_ca_system_score_gemma":0.00005373375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003637298,"about_ca_topic_score_gemma":8.397446e-7,"domain_scores_codex":[0.9992077,0.000008556752,0.0003642504,0.00006015888,0.0002774998,0.00008185268],"domain_scores_gemma":[0.9996147,0.000007985747,0.000169623,0.00005809909,0.0001071408,0.00004250529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002335409,0.00009237779,0.006100521,0.00007131485,0.00002036477,0.00000125335,0.00004915226,0.000001087577,0.9926105,0.0005359306,0.00008654751,0.0001974073],"study_design_scores_gemma":[0.000981228,0.00002122398,0.4068146,0.00009598662,0.0000356552,0.00007962679,0.00001903049,0.00005049962,0.5913703,0.0001883744,0.0003082852,0.00003518],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954529,0.00006003433,0.003600781,0.0005084566,0.00009011207,0.00012893,0.00003362738,0.000004848156,0.0001203039],"genre_scores_gemma":[0.9990284,0.00001326885,0.0005236157,0.00004956479,0.0001207043,0.000001745792,0.00008868417,0.000005346365,0.0001686592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4012402,"threshold_uncertainty_score":0.1765484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007594584497078951,"score_gpt":0.1955879606058245,"score_spread":0.1879933761087455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}