{"id":"W1997996171","doi":"10.1042/bj20060015","title":"Conformational and functional characterization of trapped complexes of the P-glycoprotein multidrug transporter","year":2006,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"Transporter; P-glycoprotein; Chemistry; Multiple drug resistance; Characterization (materials science); Glycoprotein; Biochemistry; Stereochemistry; Computational biology; Biology; Gene; Nanotechnology; Materials science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002227816,0.0002871337,0.0001884694,0.00009706059,0.0001402301,0.0003440793,0.0004267994,0.0003537529,0.0006753748],"category_scores_gemma":[0.0004120321,0.0001480156,0.0001727747,0.0001304735,0.0002209615,0.0002830456,0.0001710138,0.0003773926,0.0002439307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003233027,"about_ca_system_score_gemma":0.00009167084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006771413,"about_ca_topic_score_gemma":0.0005127701,"domain_scores_codex":[0.9998195,0.00004036431,0.00001383053,0.00004407236,0.00005057462,0.00003173907],"domain_scores_gemma":[0.9998192,0.00004871065,0.00004159598,0.00002302506,0.00003456963,0.00003293272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004467957,0.00001437751,0.0001306293,0.00002394599,0.00000782701,0.00003295404,0.0000352694,0.00005526411,0.9992316,0.00007008981,0.00001416328,0.0003391747],"study_design_scores_gemma":[0.00001339796,0.0001622073,0.002702996,0.00000416287,0.00001371146,0.0002512852,0.00004179994,0.001418533,0.9943469,0.00003519902,0.001000124,0.000009602185],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967574,0.0005526235,0.00215294,0.00002938109,0.000005760659,0.00001262638,0.00008903028,0.00001690374,0.0003833756],"genre_scores_gemma":[0.9955532,0.0002967641,0.002160381,0.00003814272,0.00000476546,0.00002644835,0.0004826808,0.00002492685,0.001412635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006771413,"threshold_uncertainty_score":0.002345681,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007594584497078951,"score_gpt":0.1955879606058245,"score_spread":0.1879933761087455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}