{"id":"W1997996573","doi":"10.1038/npp.2009.161","title":"Low Doses of 17α-Estradiol and 17β-Estradiol Facilitate, Whereas Higher Doses of Estrone and 17α- and 17β-Estradiol Impair, Contextual Fear Conditioning in Adult Female Rats","year":2009,"lang":"en","type":"article","venue":"Neuropsychopharmacology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":127,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Fondation pour la Recherche sur Alzheimer; Smith and Nephew","keywords":"Hippocampus; Ovariectomized rat; Estrone; Estrogen; Endocrinology; Internal medicine; Synaptophysin; Fear conditioning; Context (archaeology); Conditioning; Psychology; Testosterone (patch); Neuroscience; Amygdala; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001807091,0.0003965888,0.0005946725,0.0001506133,0.00009303054,0.00002237586,0.0001647009,0.0003751154,0.00002534884],"category_scores_gemma":[0.00005934274,0.000381164,0.00008913258,0.000138926,0.0006448016,0.00002856707,0.00005114662,0.0004391094,0.000001915184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001268894,"about_ca_system_score_gemma":0.00007273139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004843644,"about_ca_topic_score_gemma":0.000007737868,"domain_scores_codex":[0.9977751,0.000364942,0.0005677896,0.0006885129,0.0001403273,0.0004632709],"domain_scores_gemma":[0.9990422,0.0001354757,0.0002428279,0.0002399433,0.00009166888,0.0002478519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001311962,0.0003321579,0.01353064,0.0001329755,0.0001300376,0.0001085625,0.0002084949,0.00004209312,0.9791353,0.0001446887,0.0008779671,0.004045075],"study_design_scores_gemma":[0.01904383,0.01330574,0.4481485,0.0002625645,0.0003162332,0.001325569,0.0004252585,0.0002200309,0.514689,0.0002327049,0.0009550886,0.001075482],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946018,0.003595495,0.000009936191,0.0002268191,0.0002533927,0.0005782853,0.00009210442,0.00002386251,0.0006183173],"genre_scores_gemma":[0.9960786,0.002983357,0.0001835371,0.0003535483,0.0001233309,0.00002484972,0.00005318037,0.00003236053,0.0001672554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4644463,"threshold_uncertainty_score":0.999864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008656376950965002,"score_gpt":0.2625069876046045,"score_spread":0.2538506106536395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}