{"id":"W1997996573","doi":"10.1038/npp.2009.161","title":"Low Doses of 17α-Estradiol and 17β-Estradiol Facilitate, Whereas Higher Doses of Estrone and 17α- and 17β-Estradiol Impair, Contextual Fear Conditioning in Adult Female Rats","year":2009,"lang":"en","type":"article","venue":"Neuropsychopharmacology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":127,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Fondation pour la Recherche sur Alzheimer; Smith and Nephew","keywords":"Hippocampus; Ovariectomized rat; Estrone; Estrogen; Endocrinology; Internal medicine; Synaptophysin; Fear conditioning; Context (archaeology); Conditioning; Psychology; Testosterone (patch); Neuroscience; Amygdala; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002299183,0.0009863437,0.000686417,0.0004814739,0.0002326198,0.0003693593,0.0004176738,0.0003994554,0.003459927],"category_scores_gemma":[0.0002581804,0.0004822506,0.0002665986,0.0002339912,0.001073511,0.0005727147,0.00039507,0.001347932,0.0006034893],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004493795,"about_ca_system_score_gemma":0.0006135894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001672057,"about_ca_topic_score_gemma":0.004423779,"domain_scores_codex":[0.9997631,0.00002287095,0.00002037299,0.00005116194,0.00005549716,0.00008694029],"domain_scores_gemma":[0.9994053,0.00006035884,0.0001802972,0.00006575909,0.00002577379,0.0002626638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002962932,0.0002355988,0.000604517,0.00004168811,0.00001257562,0.00008641998,0.00005660371,0.00004846598,0.9931137,0.0001577163,0.00006246439,0.002617403],"study_design_scores_gemma":[0.0002242043,0.004160586,0.01942193,0.00002265169,0.00005257542,0.0004239105,0.0001783641,0.0003857309,0.9737157,0.0003022101,0.001088721,0.00002337028],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977657,0.00041612,0.000548936,0.0001324564,0.00003527453,0.0000147292,0.0002806882,0.0000642034,0.0007418339],"genre_scores_gemma":[0.9872967,0.001325228,0.001666907,0.0001833722,0.00003668298,0.00007850557,0.0004773335,0.0000620362,0.008873175],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003459927,"threshold_uncertainty_score":0.01157463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008656376950965002,"score_gpt":0.2625069876046045,"score_spread":0.2538506106536395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}