{"id":"W1998025335","doi":"10.1073/pnas.0910957106","title":"Multiple myeloma phosphotyrosine proteomic profile associated with FGFR3 expression, ligand activation, and drug inhibition","year":2009,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Princess Margaret Cancer Centre; Hospital for Sick Children; University of Toronto","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Receptor tyrosine kinase; Fibroblast growth factor receptor 3; Tyrosine kinase; Chemistry; Phosphorylation; Biology; Fibroblast growth factor receptor; Molecular biology; Cancer research; Signal transduction; Fibroblast growth factor; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005199114,0.00008378732,0.00008869572,0.00006807059,0.0001684576,0.0000233148,0.0002099791,0.00007893198,0.000002717511],"category_scores_gemma":[0.0007634209,0.00005357493,0.00002353645,0.0003401324,0.0004170429,0.00004832151,0.00007706675,0.0001017042,1.856365e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001592853,"about_ca_system_score_gemma":0.00004028258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002162883,"about_ca_topic_score_gemma":9.149471e-8,"domain_scores_codex":[0.9988467,0.000007775367,0.0001677884,0.0002350174,0.0006127636,0.0001300324],"domain_scores_gemma":[0.9993405,0.00002658396,0.0002545317,0.000008723944,0.0003380623,0.00003155523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007208998,0.00004161542,0.01198304,0.00001695859,0.000005740361,2.093276e-9,0.00005790414,0.000009637442,0.9866521,0.0002188606,0.0008714937,0.00007056881],"study_design_scores_gemma":[0.000279858,0.0001293057,0.2111266,0.0001350663,0.000001998273,0.000001770619,0.00003230487,0.0000863961,0.787102,0.0010306,0.00001936257,0.00005475717],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979259,0.00003620876,0.000002436332,0.001284092,0.000002463335,0.0003193928,0.00001367301,0.000005808237,0.0004099922],"genre_scores_gemma":[0.9989461,0.000007934193,0.0007455054,0.00009653813,0.00003162136,0.00001564876,0.000002251174,0.000004020268,0.0001504209],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1995501,"threshold_uncertainty_score":0.2184722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01525476090963725,"score_gpt":0.2661865833745523,"score_spread":0.2509318224649151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}