{"id":"W1998043937","doi":"10.1021/ja900867q","title":"Structure Proof and Synthesis of Kotalanol and De-<i>O</i>-sulfonated Kotalanol, Glycosidase Inhibitors Isolated from an Herbal Remedy for the Treatment of Type-2 Diabetes","year":2009,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Sulfonium; Acetal; Stereochemistry; Nucleophile; Ring (chemistry); Thio-; Methylene; Adduct; Medicinal chemistry; Organic chemistry; Salt (chemistry)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009905008,0.0002057713,0.0005381455,0.000008517212,0.00007320964,0.00002149615,0.0002452032,0.0001250285,0.00002091435],"category_scores_gemma":[0.000191046,0.0001164095,0.0003349,0.0001619615,0.0004562649,0.0000569454,0.00002960111,0.0001759485,1.869883e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001063826,"about_ca_system_score_gemma":0.00006429201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004226929,"about_ca_topic_score_gemma":0.000001040853,"domain_scores_codex":[0.9989427,0.00002953608,0.000440703,0.0001762595,0.0002023602,0.0002084915],"domain_scores_gemma":[0.9980628,0.0006582107,0.0007699502,0.0002676651,0.0001301418,0.0001112595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003420847,0.0002510252,0.002623135,0.00004438923,0.0003857441,7.983343e-7,0.000600617,0.000009157249,0.9833,5.854925e-7,0.000152766,0.01228973],"study_design_scores_gemma":[0.0005810224,0.0002358709,0.0008046988,0.000101741,0.0004016575,0.00001495725,0.0006538825,0.001210754,0.9955188,0.0002075076,0.0001435555,0.0001255256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998149,0.0008368752,0.000002738415,0.0007257298,0.00002560074,0.00008214285,0.0001558965,0.00000767164,0.0000143965],"genre_scores_gemma":[0.9988822,0.00036967,0.0004409444,0.00008332338,0.0001876336,0.000003403411,0.000005174272,0.00001619311,0.00001144745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01221886,"threshold_uncertainty_score":0.474704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006196569174820375,"score_gpt":0.2255937738152085,"score_spread":0.2193972046403882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}