{"id":"W1998043937","doi":"10.1021/ja900867q","title":"Structure Proof and Synthesis of Kotalanol and De-<i>O</i>-sulfonated Kotalanol, Glycosidase Inhibitors Isolated from an Herbal Remedy for the Treatment of Type-2 Diabetes","year":2009,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Sulfonium; Acetal; Stereochemistry; Nucleophile; Ring (chemistry); Thio-; Methylene; Adduct; Medicinal chemistry; Organic chemistry; Salt (chemistry)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009794378,0.0003783756,0.0001821087,0.0002677809,0.0002091053,0.0001750871,0.0002658627,0.0002417246,0.002060267],"category_scores_gemma":[0.0001329814,0.0001294109,0.0002796561,0.0002998167,0.0001652705,0.0002766884,0.0002414935,0.0004200505,0.001040355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000181719,"about_ca_system_score_gemma":0.0005647431,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006335636,"about_ca_topic_score_gemma":0.001090814,"domain_scores_codex":[0.9999139,0.00001125722,0.000009418243,0.00001312542,0.00002323059,0.00002901297],"domain_scores_gemma":[0.9999299,0.000006911751,0.00001580077,0.000009888444,0.00002011176,0.00001732527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001209457,0.0001012676,0.0001357901,0.0002371168,0.00001285858,0.000490534,0.00008464178,0.0007142448,0.9844686,0.002027283,0.0003025712,0.01130402],"study_design_scores_gemma":[0.00005007593,0.0009314514,0.0008496569,0.00001476444,0.00002214165,0.0003480762,0.00005609142,0.0008003211,0.9812176,0.0003400819,0.01535401,0.00001574294],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8826392,0.004069127,0.06717558,0.0006102313,0.0003206309,0.0009333975,0.003391429,0.0003850105,0.04047546],"genre_scores_gemma":[0.9599732,0.003966692,0.02598273,0.0001522495,0.00004886165,0.0001507613,0.001779945,0.00005030386,0.007895163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002060267,"threshold_uncertainty_score":0.006892264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006196569174820375,"score_gpt":0.2255937738152085,"score_spread":0.2193972046403882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}