{"id":"W1998049068","doi":"10.1006/abbi.2000.2232","title":"Mechanism of Acetaminophen Inhibition of Cyclooxygenase Isoforms","year":2001,"lang":"en","type":"article","venue":"Archives of Biochemistry and Biophysics","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":167,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Acetaminophen; Cyclooxygenase; Chemistry; Antipyretic; Pharmacology; IC50; Analgesic; Mechanism of action; Glutathione; Potency; Enzyme; Biochemistry; In vitro; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004883746,0.00009930911,0.0002564362,0.00003295037,0.00001821431,0.000001087005,0.00003594354,0.0000554871,0.000006408868],"category_scores_gemma":[0.00002365821,0.00007927539,0.00009100222,0.00007882512,0.0002174368,0.00002621621,0.0000371615,0.00006613482,5.172622e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002828478,"about_ca_system_score_gemma":0.0000360144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000835393,"about_ca_topic_score_gemma":1.407172e-7,"domain_scores_codex":[0.9994261,0.00000829805,0.0002217007,0.0001195518,0.000117827,0.0001064866],"domain_scores_gemma":[0.9995223,0.00004693778,0.0001612089,0.0001701446,0.00003026251,0.00006917404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002631033,0.0001534818,0.0009542167,0.001013357,0.00003978331,0.000009811301,0.0002420851,4.047903e-7,0.9907042,0.0007683437,0.000006368057,0.005844846],"study_design_scores_gemma":[0.0007989503,0.0002650734,0.002479033,0.0002727411,0.00005578982,0.00001684891,0.0001169624,0.0001548497,0.993444,0.00231087,0.00001340808,0.00007145048],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982089,0.0001155113,0.0001647659,0.00003245411,0.00002212887,0.0001037127,0.00002710013,0.000007505395,0.001317901],"genre_scores_gemma":[0.9990025,0.0002435274,0.0005186084,0.00001620975,0.00007868202,0.000002687196,0.00003291528,0.000006982534,0.00009794525],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005773395,"threshold_uncertainty_score":0.3232757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005684831407227421,"score_gpt":0.212626358210994,"score_spread":0.2069415268037666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}