{"id":"W1998063413","doi":"10.7554/elife.03574","title":"Discovery of a small molecule that inhibits bacterial ribosome biogenesis","year":2014,"lang":"en","type":"article","venue":"eLife","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of General Medical Sciences; National Institutes of Health; Canada Research Chairs; Canadian Institutes of Health Research; Ontario Council on Graduate Studies, Council of Ontario Universities; Natural Sciences and Engineering Research Council of Canada; McMaster University; Jane Coffin Childs Memorial Fund for Medical Research","keywords":"Biogenesis; Ribosome; Ribosome biogenesis; Small molecule; Computational biology; Biology; Chemical biology; Structural biology; Cell biology; Chemistry; Genetics; RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002034296,0.0001341856,0.0001673331,0.00003327675,0.00003547948,0.00002234191,0.0001783484,0.0001354617,0.00002228177],"category_scores_gemma":[0.0001024028,0.0001199309,0.0001144936,0.0000464263,0.00004130196,0.000004125993,0.0001062203,0.00002635643,0.00001778445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003808416,"about_ca_system_score_gemma":0.00003355664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000242261,"about_ca_topic_score_gemma":0.00001549062,"domain_scores_codex":[0.9991742,0.00009107449,0.0001672685,0.0002550833,0.0001306795,0.0001816643],"domain_scores_gemma":[0.999448,0.0000134759,0.0001002178,0.0003454538,0.00004095133,0.00005187815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007747707,0.00003304985,0.0004812179,0.00001574575,0.00002664189,4.730116e-7,0.00001221385,0.000001824101,0.9976859,0.0002133678,0.0002078017,0.001244306],"study_design_scores_gemma":[0.0002972063,0.0001944276,0.0006179205,0.00001805518,0.00001366384,0.000003205269,0.000009488277,0.000005863428,0.9901157,0.00005246511,0.008522126,0.0001498953],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902103,0.0002407393,0.008304319,0.00006608475,0.0002131076,0.0001209092,0.00003636174,0.000009830836,0.0007983788],"genre_scores_gemma":[0.99748,0.00009408291,0.001289564,0.0002048494,0.0003432094,0.00001956121,0.00006920456,0.00002410115,0.0004753757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008314325,"threshold_uncertainty_score":0.489064,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01355688597059748,"score_gpt":0.2141543008922541,"score_spread":0.2005974149216566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}