{"id":"W1998084353","doi":"10.1016/j.bpj.2012.11.1488","title":"S4-S5 Linker Flexibility Stabilizes hERG Channel Closed States","year":2013,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"","keywords":"hERG; Gating; Shaker; Linker; Chemistry; Biophysics; Allosteric regulation; Depolarization; Crystallography; Stereochemistry; Potassium channel; Biochemistry; Physics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002793888,0.0002504588,0.0002200419,0.0001176467,0.0004735784,0.0004112588,0.0003588148,0.0004554479,0.006623966],"category_scores_gemma":[0.0005720769,0.0001577545,0.0002689168,0.00009341261,0.0004050609,0.0005708829,0.0005530862,0.000505611,0.00069741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002146436,"about_ca_system_score_gemma":0.0002305485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004148787,"about_ca_topic_score_gemma":0.0006307059,"domain_scores_codex":[0.9998438,0.00002690647,0.00001276781,0.00003571872,0.0000293617,0.00005149562],"domain_scores_gemma":[0.9997028,0.0001001634,0.00006715847,0.0000322589,0.00002679324,0.00007078157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001618437,0.0001019437,0.001658189,0.0001167153,0.00007192566,0.0004658341,0.000126182,0.001617201,0.984543,0.001676769,0.000400156,0.007603475],"study_design_scores_gemma":[0.0003560377,0.001305236,0.01080228,0.00007826815,0.0001229402,0.000801397,0.0002887804,0.01243827,0.9663482,0.001198924,0.006186391,0.0000732322],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970041,0.0001935487,0.001373773,0.00007095937,0.00003664129,0.000008759876,0.00005899823,0.00007458879,0.001178691],"genre_scores_gemma":[0.9992249,0.00003786427,0.0001968545,0.00005221843,0.000005043046,0.000003110918,0.00006891196,0.0000131525,0.0003979191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006623966,"threshold_uncertainty_score":0.02215934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01639899558361159,"score_gpt":0.2731763335737555,"score_spread":0.2567773379901439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}