{"id":"W1998092518","doi":"10.1021/tx200141p","title":"The p38 MAPK Inhibitor SB203580 Induces Cytochrome P450 1A1 Gene Expression in Murine and Human Hepatoma Cell Lines through Ligand-Dependent Aryl Hydrocarbon Receptor Activation","year":2011,"lang":"en","type":"article","venue":"Chemical Research in Toxicology","topic":"Toxic Organic Pollutants Impact","field":"Environmental Science","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Environmental Health Sciences; University of Alberta","keywords":"Aryl hydrocarbon receptor; p38 mitogen-activated protein kinases; Cytochrome P450; Gene expression; MAPK/ERK pathway; Chemistry; Messenger RNA; Cell biology; Enzyme inducer; Cell culture; Molecular biology; CYP1B1; Gene; Biochemistry; Biology; Enzyme; Signal transduction; Transcription factor; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002250058,0.0006540935,0.0003509874,0.0003720135,0.0002506985,0.000208727,0.0001419685,0.0001886125,0.002272316],"category_scores_gemma":[0.0001083629,0.000199699,0.0004067603,0.000292702,0.0002155027,0.0001214799,0.0002149291,0.0005948035,0.0007884785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000221343,"about_ca_system_score_gemma":0.000308491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009426029,"about_ca_topic_score_gemma":0.001485412,"domain_scores_codex":[0.9997663,0.00004947144,0.00002375595,0.00003949838,0.00005900966,0.00006208624],"domain_scores_gemma":[0.9999385,0.00001305146,0.0000131824,0.000008177179,0.00001259652,0.0000144245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002685144,0.0001050856,0.0001329028,0.00007662927,0.000007954985,0.00007379873,0.00002354097,0.00005132033,0.9973435,0.00004681498,0.000131953,0.001738046],"study_design_scores_gemma":[0.00006067302,0.000785345,0.003521993,0.000007993086,0.00002126179,0.0002574985,0.00002714542,0.0008191268,0.9910104,0.00004000753,0.003443334,0.000005135068],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854478,0.005098133,0.004848661,0.0003218257,0.0001128017,0.0001101561,0.0009775358,0.0002529701,0.002830199],"genre_scores_gemma":[0.9777821,0.004091547,0.007805273,0.0001383433,0.00006403332,0.000331302,0.002417957,0.00004683184,0.007322665],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002272316,"threshold_uncertainty_score":0.007601619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06591832886176346,"score_gpt":0.3300858487699506,"score_spread":0.2641675199081872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}