{"id":"W1998095124","doi":"10.1161/01.cir.0000014211.47830.4d","title":"Inhibition of Calcineurin and Sarcolemmal Ca <sup>2+</sup> Influx Protects Cardiac Morphology and Ventricular Function in K <sub>v</sub> 4.2N Transgenic Mice","year":2002,"lang":"en","type":"article","venue":"Circulation","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Contractility; Calcineurin; Internal medicine; Endocrinology; Phospholamban; Medicine; SERCA; Endoplasmic reticulum; Heart failure; Cardiac function curve; Myocyte; Calcium; Genetically modified mouse; Transgene; ATPase; Biology; Cell biology; Transplantation; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001527534,0.0001297141,0.0001519964,0.00009182335,0.00004211533,0.000009534883,0.00003059788,0.000189966,0.000007399423],"category_scores_gemma":[0.00007194329,0.0001502142,0.00005573118,0.00014561,0.00006942906,0.00001156295,0.00002520092,0.00008689078,0.000003280816],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002257063,"about_ca_system_score_gemma":0.000017837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001884589,"about_ca_topic_score_gemma":0.0000034576,"domain_scores_codex":[0.9990391,0.0001280823,0.000234874,0.0003277754,0.0001097496,0.0001604591],"domain_scores_gemma":[0.9996298,0.0000133982,0.00007836007,0.0001579137,0.00005821976,0.00006229177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006769518,0.00005714901,0.02667083,0.00008608502,0.0000228133,0.000006854205,0.0001290597,0.007092127,0.9641969,0.000007705818,0.00005092641,0.00161188],"study_design_scores_gemma":[0.001472807,0.0001870323,0.1420819,0.0000500164,0.0000741804,0.00002854868,0.00004583372,0.006616339,0.8489853,0.0001023363,0.0001304468,0.0002251798],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968487,0.001752159,0.0007764097,0.00003656115,0.00004706087,0.000478982,0.00002807425,0.00001084352,0.00002119005],"genre_scores_gemma":[0.9995131,0.00007008446,0.00003096577,0.0000546128,0.0001053382,0.00005511457,0.0001515828,0.0000171938,0.000001977331],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1154111,"threshold_uncertainty_score":0.6125556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01136279198206343,"score_gpt":0.2053342277805029,"score_spread":0.1939714357984395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}