{"id":"W1998095124","doi":"10.1161/01.cir.0000014211.47830.4d","title":"Inhibition of Calcineurin and Sarcolemmal Ca <sup>2+</sup> Influx Protects Cardiac Morphology and Ventricular Function in K <sub>v</sub> 4.2N Transgenic Mice","year":2002,"lang":"en","type":"article","venue":"Circulation","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Contractility; Calcineurin; Internal medicine; Endocrinology; Phospholamban; Medicine; SERCA; Endoplasmic reticulum; Heart failure; Cardiac function curve; Myocyte; Calcium; Genetically modified mouse; Transgene; ATPase; Biology; Cell biology; Transplantation; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002233493,0.000786606,0.0004221488,0.0004519422,0.0002358377,0.0003795488,0.0005848093,0.0006321721,0.001688024],"category_scores_gemma":[0.0001864226,0.0003634738,0.0003127452,0.0001406744,0.0005778383,0.0004276642,0.0002857791,0.000672323,0.000456937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004913953,"about_ca_system_score_gemma":0.0003422677,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006284527,"about_ca_topic_score_gemma":0.001278782,"domain_scores_codex":[0.9997991,0.00002491408,0.00003226142,0.00004665367,0.00005174921,0.00004531581],"domain_scores_gemma":[0.999519,0.00003149604,0.0002407971,0.00003270379,0.00003268349,0.0001433898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004309571,0.00006430348,0.0002033932,0.00002523495,0.000006823466,0.00006386863,0.00001391028,0.00003479024,0.9986331,0.000061133,0.00002628776,0.0004362536],"study_design_scores_gemma":[0.0003318142,0.001738944,0.01072512,0.00003308803,0.00007108777,0.0009287881,0.00007950648,0.001399357,0.9825066,0.0001470918,0.002021957,0.00001668497],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966261,0.000516671,0.001506885,0.00009048596,0.00002651561,0.00003907263,0.0003566844,0.0001451462,0.0006923549],"genre_scores_gemma":[0.990056,0.0005442779,0.002854062,0.00008301704,0.00002958862,0.000153025,0.0006838507,0.0001003473,0.005495783],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001688024,"threshold_uncertainty_score":0.005647063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01136279198206343,"score_gpt":0.2053342277805029,"score_spread":0.1939714357984395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}