{"id":"W1998099926","doi":"10.1016/j.chembiol.2007.03.004","title":"When an Inhibitor Promotes Activity","year":2007,"lang":"en","type":"letter","venue":"Chemistry & Biology","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"","keywords":"Drug discovery; Chemical biology; Biology; Computational biology; Drug; Drug target; High-throughput screening; Pharmacology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001108784,0.0005697879,0.00102431,0.0004089222,0.001020235,0.002277933,0.000851551,0.009900942,0.006399523],"category_scores_gemma":[0.005033066,0.0002946491,0.0009103861,0.0002556335,0.001771573,0.001455363,0.001034663,0.008793033,0.003647725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001622831,"about_ca_system_score_gemma":0.0008370616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005074643,"about_ca_topic_score_gemma":0.001111695,"domain_scores_codex":[0.9986773,0.0002660608,0.0001420108,0.0001857324,0.0003973162,0.0003315522],"domain_scores_gemma":[0.9984558,0.0008274232,0.000165297,0.0001073317,0.0001184675,0.000325759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001415559,0.0002782983,0.004536787,0.0005571141,0.0001744883,0.06653044,0.0003145804,0.0005075616,0.0240904,0.08537072,0.7180346,0.09818946],"study_design_scores_gemma":[0.0004820653,0.0004813853,0.00163579,0.0001666404,0.00009479536,0.03707439,0.0002494626,0.0009083131,0.02318035,0.03048115,0.9051808,0.00006488669],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.03690207,0.02966412,0.00290527,0.764803,0.03816634,0.0001179862,0.0002701025,0.0006118974,0.1265593],"genre_scores_gemma":[0.3457098,0.01938029,0.002873256,0.4965717,0.04164338,0.000268267,0.0003474272,0.0001632345,0.09304254],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.009900942,"threshold_uncertainty_score":0.0214085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0363056655965399,"score_gpt":0.3326905596648009,"score_spread":0.296384894068261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}