{"id":"W1998128193","doi":"10.1093/nar/gkq1321","title":"Reconstitution of human RNA interference in budding yeast","year":2011,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Human Genome Research Institute; Canadian Institutes of Health Research","keywords":"Dicer; Biology; RNA interference; Argonaute; Saccharomyces cerevisiae; RNA-induced silencing complex; Gene silencing; Genetics; Cell biology; Small interfering RNA; Gene; Ribonuclease III; RNA silencing; RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005258307,0.00007536742,0.0001060368,0.0001721368,0.0000553489,0.00001066924,0.0003318896,0.0001183737,0.0002345635],"category_scores_gemma":[0.00009537325,0.00007317348,0.00004244462,0.0001643562,0.0002625568,0.000007897842,0.0001964543,0.0001967638,0.00005159317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002160323,"about_ca_system_score_gemma":0.00006910305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002811153,"about_ca_topic_score_gemma":0.0001653054,"domain_scores_codex":[0.9990497,0.0001017633,0.0002026961,0.0002479533,0.0001398209,0.0002580504],"domain_scores_gemma":[0.9994506,0.000006072612,0.00003527477,0.0002895604,0.0001683042,0.00005021902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009381,0.00007187374,0.01343925,0.00001525039,0.00001139857,0.000005190682,0.0003382585,8.283692e-7,0.9794076,0.0006825676,0.0004871225,0.005446849],"study_design_scores_gemma":[0.0002812509,0.0007339322,0.01515312,0.00009866716,0.000002052661,0.000005747121,0.0007001052,0.00003227037,0.9819089,0.0005186838,0.0004554494,0.0001098815],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9525472,0.0001008766,0.0001731758,0.00001164795,0.00005525271,0.00009192057,0.000005145598,0.000004232297,0.04701056],"genre_scores_gemma":[0.9990828,0.0001004867,0.0001914835,0.00001295641,0.00005355746,0.00001190295,0.00001226535,0.000008635407,0.0005258987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04653562,"threshold_uncertainty_score":0.2983928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1086588709209232,"score_gpt":0.357183755287413,"score_spread":0.2485248843664898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}