{"id":"W1998129163","doi":"10.1021/ol501586y","title":"Diversity-Oriented Synthesis of Azapeptides with Basic Amino Acid Residues: Aza-Lysine, Aza-Ornithine, and Aza-Arginine","year":2014,"lang":"en","type":"article","venue":"Organic Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Chemistry; Alkylation; Lysine; Residue (chemistry); Azide; Arginine; Alkyl; Ornithine; Chloride; Solid-phase synthesis; Peptide synthesis; Glycine; Peptide; Stereochemistry; Amino acid; Combinatorial chemistry; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001178033,0.0003267932,0.0002488168,0.0001712497,0.0001074273,0.0002141908,0.0002252541,0.0001921482,0.0007685119],"category_scores_gemma":[0.0001216661,0.0001211772,0.0001544547,0.0002331441,0.0001485175,0.0001724819,0.0002030981,0.000424302,0.0003477123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002241123,"about_ca_system_score_gemma":0.0001728357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001981279,"about_ca_topic_score_gemma":0.0004522318,"domain_scores_codex":[0.9999049,0.00001067236,0.000007825482,0.00002790119,0.00002706666,0.00002158032],"domain_scores_gemma":[0.9999214,0.00001019129,0.00002505073,0.000008682831,0.00001657626,0.00001802278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002697051,0.000007228729,0.00006131343,0.00003386863,0.000003562307,0.00005229532,0.00001169866,0.0001513624,0.9974141,0.0001425342,0.00001688556,0.002078091],"study_design_scores_gemma":[0.000009589829,0.0001229662,0.0005434646,0.000002362198,0.00000739705,0.0002148184,0.000007108324,0.0003207984,0.9967477,0.00006447225,0.001955113,0.000004116415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9657132,0.001913828,0.02527712,0.00009885746,0.00005279905,0.0001273156,0.0007229198,0.0001363674,0.005957489],"genre_scores_gemma":[0.9666911,0.001686012,0.02723164,0.00004495075,0.00001260963,0.00007345771,0.0006485991,0.00003492528,0.003576751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007685119,"threshold_uncertainty_score":0.002570927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003419992380712667,"score_gpt":0.1730632871133652,"score_spread":0.1696432947326526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}