{"id":"W1998129163","doi":"10.1021/ol501586y","title":"Diversity-Oriented Synthesis of Azapeptides with Basic Amino Acid Residues: Aza-Lysine, Aza-Ornithine, and Aza-Arginine","year":2014,"lang":"en","type":"article","venue":"Organic Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Chemistry; Alkylation; Lysine; Residue (chemistry); Azide; Arginine; Alkyl; Ornithine; Chloride; Solid-phase synthesis; Peptide synthesis; Glycine; Peptide; Stereochemistry; Amino acid; Combinatorial chemistry; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002005641,0.0002484729,0.0003769276,0.00007313373,0.0002031207,0.0000185282,0.0002451686,0.0001188255,0.0001120054],"category_scores_gemma":[0.0002773331,0.000199325,0.0001020996,0.000234527,0.0002295654,0.00001018971,0.0003794212,0.0001030277,0.000009030917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000189834,"about_ca_system_score_gemma":0.00001845601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007027198,"about_ca_topic_score_gemma":0.00007758529,"domain_scores_codex":[0.9986644,0.00007999154,0.0002491492,0.0004927999,0.0002372348,0.00027639],"domain_scores_gemma":[0.9990965,0.00007592897,0.0001710456,0.0004591723,0.0000746854,0.0001227432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007851757,0.00005214104,0.0260863,0.00004109652,0.0002290466,0.000003609806,0.00007527999,0.000002868205,0.9710861,0.00001308981,0.001245675,0.00108624],"study_design_scores_gemma":[0.0004500628,0.0001186187,0.009350604,0.00005084965,0.0002771223,0.0000099267,0.00008405578,0.00001983316,0.9879425,0.000006648091,0.001416,0.0002737451],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996555,0.0001269567,0.001443863,0.001580267,0.00002274718,0.00007306319,0.00001768822,0.00001988362,0.000160577],"genre_scores_gemma":[0.9977456,0.00009719399,0.0008761695,0.000995014,0.0001459321,0.000005375925,0.00004099058,0.00003225141,0.00006143265],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0168564,"threshold_uncertainty_score":0.8128238,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003419992380712667,"score_gpt":0.1730632871133652,"score_spread":0.1696432947326526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}