{"id":"W1998149522","doi":"10.1007/s00702-004-0255-3","title":"Oxidative stress potentiates BACE1 gene expression and A? generation","year":2004,"lang":"en","type":"article","venue":"Journal of Neural Transmission","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":215,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Oxidative stress; Senile plaques; Amyloid precursor protein; Pathogenesis; Molecular biology; Green fluorescent protein; Amyloid precursor protein secretase; Biology; BACE1-AS; Alzheimer's disease; Downregulation and upregulation; Gene; Chemistry; Cell biology; Biochemistry; Medicine; Immunology; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007570286,0.0001135839,0.0001956148,0.000106317,0.00009983932,0.00002516001,0.00004155016,0.00005291749,0.00005739517],"category_scores_gemma":[0.00001428738,0.00007005166,0.000101355,0.00007298499,0.00003620108,0.0002632829,0.000009788837,0.0001739181,0.000002395464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000038089,"about_ca_system_score_gemma":0.00008999098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004316174,"about_ca_topic_score_gemma":3.271797e-7,"domain_scores_codex":[0.9990381,0.00004937987,0.0002452811,0.0001220626,0.0003931667,0.000152034],"domain_scores_gemma":[0.9992461,0.00001692004,0.0001103475,0.00007351965,0.0001457534,0.0004073566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008025872,0.0004936999,0.003809564,0.00004659568,0.0004833608,0.0007081562,0.0001935576,0.0001663026,0.9818662,0.00000324296,0.00008528168,0.01134147],"study_design_scores_gemma":[0.005290187,0.001327013,0.02212252,0.0004212013,0.0003047398,0.0005095635,0.00007787289,0.0003522043,0.9692783,0.0001738786,0.00005697276,0.0000855262],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878774,0.00889383,0.001617413,0.001355159,0.00005090713,0.0001567396,0.000006409792,0.000008186659,0.00003391322],"genre_scores_gemma":[0.9939194,0.001638814,0.004172002,0.00005279368,0.0001703056,0.000001456951,0.0000183153,0.00001202871,0.0000149005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01831296,"threshold_uncertainty_score":0.2856624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04006279017437994,"score_gpt":0.3183047269782725,"score_spread":0.2782419368038925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}