{"id":"W1998151496","doi":"10.1016/j.neuroimage.2012.01.119","title":"Genetic variation in CYP2A6 predicts neural reactivity to smoking cues as measured using fMRI","year":2012,"lang":"en","type":"article","venue":"NeuroImage","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Addiction and Mental Health; University of Toronto; Montreal Neurological Institute and Hospital; McGill University","funders":"National Institute on Drug Abuse; Fonds de Recherche du Québec - Santé; National Institutes of Health; Canadian Institutes of Health Research; Centre for Addiction and Mental Health Foundation; University of Toronto; Canadian Tobacco Control Research Initiative","keywords":"Nicotine; CYP2A6; Craving; Functional magnetic resonance imaging; Addiction; Insula; Neuroscience; Psychology; Smoking cessation; Amygdala; Ventral striatum; Cue reactivity; Cingulate cortex; Striatum; Medicine; Internal medicine; Central nervous system; Metabolism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004041643,0.0004180924,0.0002598993,0.0003136574,0.0002659094,0.0005449948,0.0001886154,0.0006656538,0.001869236],"category_scores_gemma":[0.001462678,0.0002601172,0.0002887686,0.0003178541,0.0003277074,0.0002213203,0.0001562101,0.0007100875,0.0001792993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001608265,"about_ca_system_score_gemma":0.0001001537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002033085,"about_ca_topic_score_gemma":0.002817189,"domain_scores_codex":[0.9997594,0.00009802687,0.00001096438,0.00007468544,0.00003636575,0.00002063635],"domain_scores_gemma":[0.9992126,0.0003416148,0.0002355321,0.00008216326,0.00003653717,0.00009146215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004022637,0.0008452426,0.8845756,0.00004769006,0.00101109,0.0006346465,0.0004031058,0.0004041147,0.09922166,0.0003164145,0.0002564006,0.008261411],"study_design_scores_gemma":[0.00001659712,0.0001716645,0.9968676,0.000002151497,0.00008226027,0.0003467613,0.00005768589,0.0006082006,0.001670831,0.00009254241,0.00007896308,0.0000048429],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991189,0.00006635994,0.0002150542,0.00005886121,0.000005844998,0.000004674776,0.00007470931,0.00000474661,0.0004509154],"genre_scores_gemma":[0.9993119,0.00004636748,0.0001868544,0.00003002295,0.000006602663,0.000005604633,0.00006403828,0.000006296311,0.0003423865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002033085,"threshold_uncertainty_score":0.006253183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02838155039537524,"score_gpt":0.2928943889005114,"score_spread":0.2645128385051362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}