{"id":"W1998164719","doi":"10.1523/jneurosci.4965-09.2010","title":"A Role for the Ubiquitin–Proteasome System in Activity-Dependent Presynaptic Silencing","year":2010,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute on Drug Abuse; National Institutes of Health; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; Howard Hughes Medical Institute","keywords":"Gene silencing; Proteasome; Depolarization; Postsynaptic potential; Cell biology; Neuroscience; Neurotransmission; Ubiquitin; Biology; Glutamate receptor; Chemistry; Biophysics; Biochemistry; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002372357,0.0003963498,0.0002828441,0.0001886684,0.00018978,0.0005194665,0.00015925,0.0002685402,0.0006882066],"category_scores_gemma":[0.0001344546,0.0001127416,0.0002457267,0.00007746634,0.000334548,0.0003276227,0.000270458,0.0004134144,0.0002589794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002787125,"about_ca_system_score_gemma":0.0001499096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001177435,"about_ca_topic_score_gemma":0.0002087188,"domain_scores_codex":[0.999904,0.00001553965,0.0000138705,0.00002345726,0.00002153736,0.00002155959],"domain_scores_gemma":[0.9998822,0.00001745427,0.00003885323,0.00002008544,0.00001488151,0.00002648464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008433109,0.00002932666,0.0005050893,0.00005690573,0.00001142454,0.0001667119,0.00001265512,0.00007869252,0.9950269,0.0003659586,0.00002547877,0.003636523],"study_design_scores_gemma":[0.00002479417,0.0006125674,0.02025959,0.00001530753,0.00004144801,0.001119797,0.00003361537,0.001918576,0.9733409,0.0004813933,0.002143335,0.00000868795],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9702166,0.01702889,0.01009005,0.0002584563,0.00005902657,0.00003100099,0.0001249504,0.0001208817,0.002070223],"genre_scores_gemma":[0.9953003,0.002298182,0.001481565,0.00003046851,0.00001593952,0.00001184801,0.00007191255,0.000003837815,0.0007859364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006882066,"threshold_uncertainty_score":0.002302229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01140544201772185,"score_gpt":0.238421836826837,"score_spread":0.2270163948091151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}