{"id":"W1998242611","doi":"10.1016/s0006-3495(01)75681-0","title":"Interaction of SNX482 with Domains III and IV Inhibits Activation Gating of α1E (CaV2.3) Calcium Channels","year":2001,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":150,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Gating; Biophysics; Depolarization; Chemistry; Calcium; Voltage-dependent calcium channel; N-type calcium channel; Alpha (finance); Calcium channel; Membrane potential; T-type calcium channel; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001929129,0.000261597,0.000404136,0.000117488,0.0002393982,0.0003981917,0.0003442726,0.0003280547,0.002498545],"category_scores_gemma":[0.0002894119,0.000154823,0.0002646841,0.0001959721,0.0003612844,0.0001633066,0.0002451055,0.0005651852,0.000728749],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004030681,"about_ca_system_score_gemma":0.0002755874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001047293,"about_ca_topic_score_gemma":0.001192509,"domain_scores_codex":[0.9997602,0.00004395734,0.00002751648,0.00003402544,0.00005243613,0.00008188881],"domain_scores_gemma":[0.9998717,0.00003693472,0.00002019279,0.00002292579,0.000008114068,0.00004009876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008972062,0.0001153796,0.0003482929,0.00004287624,0.00002826545,0.0001092603,0.00002628361,0.0001665061,0.996093,0.0002242789,0.0002744822,0.001674207],"study_design_scores_gemma":[0.0001724359,0.0007036633,0.004864588,0.000007822584,0.00002631871,0.0004384154,0.00005955994,0.001725284,0.9890056,0.00007446612,0.002913098,0.000008824034],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976841,0.0004786611,0.0003737811,0.00008107222,0.00004153084,0.000009838507,0.0001120691,0.00002558928,0.001193364],"genre_scores_gemma":[0.9969966,0.0002449992,0.000259427,0.00005214895,0.000014104,0.00001997769,0.0003903052,0.00001666984,0.002005652],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002498545,"threshold_uncertainty_score":0.008358419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01722067908559963,"score_gpt":0.2636865801051864,"score_spread":0.2464659010195868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}