{"id":"W1998255163","doi":"10.1152/ajpcell.00213.2011","title":"Human colonic epithelial cells detect and respond to C5a via apically expressed C5aR through the ERK pathway","year":2012,"lang":"en","type":"article","venue":"American Journal of Physiology-Cell Physiology","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"C5a receptor; Cell biology; Complement system; Complement membrane attack complex; MAPK/ERK pathway; Anaphylatoxin; Innate immune system; Proinflammatory cytokine; Receptor; Biology; Classical complement pathway; Mediator; Signal transduction; Alternative complement pathway; Cell; Downregulation and upregulation; Immune system; Inflammation; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001319124,0.0002490696,0.0001791344,0.000169492,0.0001714718,0.0003025811,0.00009583144,0.0002718696,0.003419362],"category_scores_gemma":[0.000149717,0.000107493,0.000244608,0.0001561934,0.0001249941,0.0001721564,0.0001857032,0.0003414385,0.0009429551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001980093,"about_ca_system_score_gemma":0.000155412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001146601,"about_ca_topic_score_gemma":0.00144463,"domain_scores_codex":[0.9997917,0.00004164334,0.00001362032,0.00002535774,0.00004893812,0.00007875793],"domain_scores_gemma":[0.9999279,0.00001733208,0.00001119477,0.00001305823,0.00002031174,0.00001029605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001631552,0.00002332364,0.0004032753,0.000039381,0.000003091352,0.00004876902,0.00002452101,0.00002495798,0.9982288,0.00004681103,0.00005062416,0.00094332],"study_design_scores_gemma":[0.00002498937,0.0003439948,0.02437836,0.00001464968,0.00002134663,0.0005583963,0.0001895523,0.001287942,0.9697521,0.00008755398,0.003331611,0.000009436571],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895307,0.002071925,0.003000015,0.0002670397,0.00002982692,0.00003796586,0.0006337091,0.00004809799,0.004380784],"genre_scores_gemma":[0.9928785,0.0007987064,0.002465919,0.0001438812,0.00001094652,0.00002660027,0.0008372224,0.000006296686,0.002831924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003419362,"threshold_uncertainty_score":0.01143891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01103096522295578,"score_gpt":0.2525709497229895,"score_spread":0.2415399845000337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}