{"id":"W1998262397","doi":"10.1212/wnl.54.6.1297","title":"Evaluation of heme oxygenase-1 as a systemic biological marker of sporadic AD","year":2000,"lang":"en","type":"article","venue":"Neurology","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":118,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"McGill University; ALS Association","keywords":"Heme oxygenase; Medicine; Internal medicine; Biomarker; Dementia; Alzheimer's disease; Gastroenterology; Disease; Endocrinology; Heme; Biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003718681,0.000341103,0.0002655352,0.0007381745,0.0001825562,0.0003263004,0.0001402302,0.000232003,0.0006854437],"category_scores_gemma":[0.0005247028,0.0001155049,0.00008669833,0.0002782473,0.0002689137,0.0001364432,0.0001668713,0.0002464933,0.0001142569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000164214,"about_ca_system_score_gemma":0.00008720794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002550791,"about_ca_topic_score_gemma":0.0002826605,"domain_scores_codex":[0.9998523,0.00004718699,0.00001136891,0.00004125035,0.00003093465,0.000016981],"domain_scores_gemma":[0.999697,0.00006583941,0.00009848166,0.00001838818,0.00007070998,0.00004968526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004441157,0.0003249208,0.5889376,0.0003559245,0.0002063301,0.001301467,0.0002604764,0.0001946654,0.3720783,0.00008976337,0.0002920652,0.03151725],"study_design_scores_gemma":[0.00008574432,0.004435577,0.9279277,0.00004000699,0.0003084296,0.006494819,0.0002531106,0.001380864,0.05757919,0.0001958437,0.00128492,0.00001386561],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968886,0.002029989,0.0005059859,0.00001469348,0.000006606884,0.00001551056,0.00005905422,0.00002096702,0.000458519],"genre_scores_gemma":[0.9987496,0.0002526509,0.0007246918,0.00001299578,0.00001575867,0.00001197084,0.00007968285,0.000002441022,0.0001502676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007381745,"threshold_uncertainty_score":0.00229305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01950913651606819,"score_gpt":0.2620769438710794,"score_spread":0.2425678073550112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}