{"id":"W1998279995","doi":"10.1210/mend.14.8.0499","title":"Human Androgen Receptor Mutation Disrupts Ternary Interactions between Ligand, Receptor Domains, and the Coactivator TIF2 (Transcription Intermediary Factor 2)","year":2000,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Sexual Differentiation and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Transactivation; Androgen receptor; Biology; Coactivator; Androgen insensitivity syndrome; Transcription factor; Mutant; Nuclear receptor; Cell biology; Androgen; RNF4; Molecular biology; Genetics; Endocrinology; Prostate cancer; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002033479,0.0007780567,0.0003428766,0.0003342043,0.0002904487,0.0002881047,0.0004672358,0.0006005269,0.002683897],"category_scores_gemma":[0.000213383,0.0002604374,0.0004763395,0.0002553784,0.00049079,0.0001408302,0.0003562331,0.0006989458,0.0008850318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003969283,"about_ca_system_score_gemma":0.0003392638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001574261,"about_ca_topic_score_gemma":0.001518713,"domain_scores_codex":[0.9996986,0.00008276228,0.00004015576,0.00005071707,0.00008078768,0.00004698621],"domain_scores_gemma":[0.9998038,0.00005391829,0.00005520555,0.00001943583,0.000009536267,0.00005806663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003004041,0.0001366571,0.000417291,0.00004855503,0.00003532599,0.001771795,0.00003745386,0.0002056806,0.994819,0.0005331642,0.0001923799,0.001502318],"study_design_scores_gemma":[0.0003216278,0.001844507,0.009308541,0.00002759375,0.000113795,0.01597468,0.000104829,0.003894398,0.9567707,0.000244915,0.01134942,0.00004508766],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938718,0.0006647637,0.002596465,0.0001340176,0.000109481,0.00008203246,0.0006654938,0.0002500469,0.001625865],"genre_scores_gemma":[0.9961845,0.0002437074,0.001158511,0.00004113495,0.00002858965,0.00003163011,0.0004730952,0.00005204589,0.001786755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002683897,"threshold_uncertainty_score":0.008978546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01045478422590166,"score_gpt":0.2697023775208243,"score_spread":0.2592475932949226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}