{"id":"W1998279995","doi":"10.1210/mend.14.8.0499","title":"Human Androgen Receptor Mutation Disrupts Ternary Interactions between Ligand, Receptor Domains, and the Coactivator TIF2 (Transcription Intermediary Factor 2)","year":2000,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Sexual Differentiation and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Transactivation; Androgen receptor; Biology; Coactivator; Androgen insensitivity syndrome; Transcription factor; Mutant; Nuclear receptor; Cell biology; Androgen; RNF4; Molecular biology; Genetics; Endocrinology; Prostate cancer; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005472239,0.0002248529,0.0002176096,0.00007429831,0.0001931009,0.00004491013,0.0001844216,0.0001275293,0.0004252801],"category_scores_gemma":[0.00003557913,0.0001857314,0.0001166138,0.00007369762,0.0003010198,0.00001677717,0.00006020745,0.0001898568,0.00006502547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002080605,"about_ca_system_score_gemma":0.0000204556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005383471,"about_ca_topic_score_gemma":0.00002747875,"domain_scores_codex":[0.998596,0.0002598214,0.0002924315,0.0004238518,0.0001230987,0.0003047777],"domain_scores_gemma":[0.9994431,0.00002923333,0.00009055994,0.0003009921,0.00004006395,0.00009604786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003874355,0.0001093996,0.004154707,0.00002132867,0.0003137334,0.00001035091,0.0004716142,0.000004527457,0.967929,0.000982521,0.00126039,0.02435501],"study_design_scores_gemma":[0.01061906,0.0008115438,0.03765103,0.00004577785,0.000199549,0.0001640699,0.0009752177,0.00004985994,0.8358223,0.001804488,0.1109394,0.0009177096],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958531,0.0005397462,0.001118059,0.0009340002,0.0002448696,0.0003642275,0.00008146638,0.00004067592,0.0008238619],"genre_scores_gemma":[0.9967782,0.0001781733,0.00009923909,0.0006331897,0.0001712791,0.00008603494,0.001267142,0.00003291106,0.0007538335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1321067,"threshold_uncertainty_score":0.7573907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01045478422590166,"score_gpt":0.2697023775208243,"score_spread":0.2592475932949226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}